Cephalonium |
Last updated: 12/01/2024 |
(Also known as: cefalonium; carbamoylcefaloridine) |
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A broad spectrum first-generation cephalosporin antibiotic used in veterinary medicine | |
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Current | |
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1948, isolated | |
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Used mainly for the treatment of bovine mastitis | |
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Cattle |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₂₀H₁₈N₄O₅S₂ | |
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C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=C(C=C4)C(=O)N | |
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C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=C(C=C4)C(=O)N | |
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FMZXNVLFJHCSAF-DNVCBOLYSA-N | |
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InChI=1S/C20H18N4O5S2/c21-17(26)11-3-5-23(6-4-11)9-12-10-31-19-15(18(27)24(19)16(12)20(28)29)22-14(25)8-13-2-1-7-30-13/h1-7,15,19H,8-10H2,(H3-,21,22,25,26,28,29)/t15-,19-/m1/s1 | |
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Yes |
General status |
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Medicinal drug, Antibiotic, Antibacterial | |
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Cephalosporin | |
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Synthetic | |
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Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. | |
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[Beta-lactamase, Agonist] | |
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5575-21-3 | |
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226-948-7 | |
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13489313 | |
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Antiinfectants for systemic use: Antibacterials for intramammary use | |
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QJ51DA90 | |
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No | |
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Allowed substance (Table 1: Bovine) | |
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458.51 | |
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(6R,7R)-3-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | |
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7-(α-thienylacetamido)-3-(4-carbamoylpyridinomethyl)-3-cephem-4-carboxylic acid | |
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White or almost white crystalline powder |
Formulations |
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Cepravin Dry Cow 250mg Intramammary suspension | Norbrook Laboratories Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Arentor DC Intramammary Suspenson | Univet Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Seclaris Intramammary Suspension for dry cows | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as a solution for intramammary injection |
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148 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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3.3 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Max: 233nm = 16650, 262nm = 13550 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2750 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2750 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 2750 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Slowly absorbed from the udder and excreted primarily in the urine. | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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cephalonium | ||
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céfalonium | ||
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cefalonio | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |