Maropitant |
Last updated: 14/03/2024 |
(Not known by any other names) |
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A veterinary antiemetic drug | |
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Current | |
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2007, first approved USA | |
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Used for the prevention of acute vomiting and to control motion sickness | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₃₂H₄₀N₂O | |
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OMPCVMLFFSQFIX-CONSDPRKSA-N | |
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InChI=1S/C32H40N2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3/t30-,31-/m0/s1 | |
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Yes |
General status |
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Medicinal drug, Antiemetic | |
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Unclassified substance | |
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Synthetic | |
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Blocks the pharmacological action of substance P in the central nervous system (CNS). | |
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[Neurokinin (NK1) receptor, Antagonist] | |
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147116-67-4 | |
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Alimentary tract & metabolism:Antiemetics and antinauseants | |
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QA04AD90 | |
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No | |
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468.67 | |
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(7R,8S)-N-[(5-tert-Butyl-2-methoxyphenyl)methyl]-7-[di(phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine | |
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Formulations |
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Arocenia Solution for Injection | Krda D.D. Novo Mesto | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Cerenia 16 mg tablets for dogs | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Vetemex Solution for Injection | CP Pharma Handelsgesellschaft mbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Vominil Solution for Injection | VetViva Richter GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually supplied as solutions for injection or tablets for oral administration |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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0.68 | E3 E = Manufacturers safety data sheets Cyprinodon variegatus as citrate (marine species)3 = Unverified data of known source |
Moderate | ||||||||
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0.68 | E3 E = Manufacturers safety data sheets Americamysis bahia3 = Unverified data of known source |
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General |
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> 2000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Mainly eliminated through the liver | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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In dogs toxicity symptoms include hypersalivation, diarrhoea, bloody stools, drooling, retching, lethargy, loss of appetite, muscle tremors, and flatulence |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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maropitant | ||
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Record last updated: | 14/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |