Flugestone acetate |
Last updated: 18/05/2024 |
(Also known as: cronolone; flurogestone; flurogestone acetate; NSC-65411; fluorogesterone acetate) |
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A progestin medication which is used in veterinary medicine. | |
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Current | |
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1959, first synthesised | |
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Drug used for intravaginal use in sheep and goats to induce oestrus synchronisation | |
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Sheep; Goats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₃H₃₁FO₅ | |
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CC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)OC(=O)C | |
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CC(=O)[C@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)CC[C@@]43C)F)O)C)OC(=O)C | |
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JKQQZJHNUVDHKP-FQJIPJFPSA-N | |
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InChI=1S/C23H31FO5/c1-13(25)22(29-14(2)26)10-8-17-18-6-5-15-11-16(27)7-9-20(15,3)23(18,24)19(28)12-21(17,22)4/h11,17-19,28H,5-10,12H2,1-4H3/t17-,18-,19-,20-,21-,22-,23-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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flugestone acetate | - |
General status |
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Medicinal drug, Breeding control | |
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Corticosteroid hormone | |
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Synthetic | |
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A synthetic progesterone | |
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2529-45-5 | |
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219-776-9 | |
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Genito urinary system & sex hormones: Genito urinary system and sex hormones - Progestagen | |
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QG03D | |
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No | |
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Allowed substance (Table 1: Ovine, Caprine) | |
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406.49 | |
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- | |
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[(9R,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate | |
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9α-fluoro-11-hydroxy,17α-acetoxy progesterone | |
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White to almost white crystalline powder |
Formulations |
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Chronogest CR, 20 mg controlled release vaginal sponge for sheep | MSD Animal Health UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Currently available products are formulated as controlled release vaginal sponges |
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266 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.07 X 1002 | Calculated | - | |||||||
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2.03 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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In methanol: 238nm = 17500 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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Flugestone acetate is metabolised into hydroxylated metabolites, which are excreted in faeces and urine | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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flugestone acetate | ||
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acétate de flugestone | ||
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acetato de flugestona | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |