Clindamycin |
Last updated: 13/01/2024 |
(Also known as: 7(S)-chloro-7-deoxylincomycin; chlolincocin; chlorlincocin; U-21251) |
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A lincosamide veterinary antibiotic used to treat a range of bacterial infections | |
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Current | |
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1966, first synthesised | |
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Used primarily to treat infections caused by susceptible anaerobic bacteria and is effective against bacteria that infect the skin, oral cavity, bone and respiratory tract | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₈H₃₃ClN₂O₅S | |
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CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl | |
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CCC[C@@H]1C[C@H](N(C1)C)C(=O)NC([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl | |
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KDLRVYVGXIQJDK-GOBYPPTJSA-N | |
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InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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Clindamycin hydrochloride monohydrate | Variant |
General status |
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Antibiotic, Antibacterial, Medicinal drug | |
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Lincosamide | |
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Semi-synthetic | |
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A bacterial protein synthesis inhibitor that works by inhibiting ribosomal translocation | |
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[50S ribosomal protein L10, Antagonist], [23S rRNA, Antagonist] | |
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18323-44-9 | |
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242-209-1 | |
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446598 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01FF01 | |
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No | |
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424.98 | |
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(2S,4R)-N-{2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide | |
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methyl-7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio--threo-a-D-galacto-octopyranoside | |
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Yellow, amorphous solid as parent, white liquid as phosphate | |
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Formulations |
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Antirobe Capsules | Zoetis UK Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Clinacin tablets | Chanelle Animal Health Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Mycinor Tables | Norbrook Laboratories Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Zondon Solution | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available as capsules, tablets and solutions for oral administration |
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30.6 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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141 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Decomposes before boiling | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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334 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.45 X 1002 | Calculated | - | |||||||
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2.16 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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1.29 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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7.02 X 10-12 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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Stable | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Stable | |||||||
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Hydrolysis not expected under environmental conditions | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 1 = Estimated data with little or no verification |
Moderately mobile | |||||||
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360 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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1832 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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1832 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Subcutaneous LD₅₀ = 2618 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted mainly in bile with around 20% eliminated in the faeces and urine. Secreted in breast milk. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause severe intestinal problems including diarrhoea, nausea & colitis |
Handling issues |
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In a fire may decompose and produce irritating vapors and toxic compounds | |||
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Not listed (Not listed) | |||
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clindamycin | ||
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clindamycine | ||
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clindamicina | ||
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Record last updated: | 13/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |