Ketoprofen |
Last updated: 18/05/2024 |
(Also known as: m-benzoylhydratropic acid ) |
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A veterinary non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation | |
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Current | |
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circa 1990, introduced | |
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Most commonly prescribed for musculoskeletal pain from soft-tissue injury, osteoarthritis or other bone and joint problems. Also used to reduce or control fevers due to viral or bacterial infections. | |
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Dogs; Cats; Horses; Goats; Sheep; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₆H₁₄O₃ | |
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CC(C1=CC=CC(=C1)C(=O)C2=CC=CC=C2)C(=O)O | |
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C[C@H](C1=CC=CC(=C1)C(=O)C2=CC=CC=C2)C(=O)O | |
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DKYWVDODHFEZIM-LLVKDONJSA-N | |
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InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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ketoprofen | - |
General status |
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Anti-inflammatory, Analgesic, Medicinal drug | |
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Propionic acid based substance | |
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Synthetic | |
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Works by inhibiting the body's production of prostaglandins, thromboxane and other inflammatory mediators | |
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[Prostaglandin G/H synthase 1, Inhibitor], [Prostaglandin G/H synthase 2, inhibitor], [High affinity interleukin-8 receptor A] | |
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56105-81-8 | |
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Musculo-skeletal system: Anti-inflammatory & antirheumatic products | |
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QM01AE03 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine, Equidae) | |
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254.28 | |
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(RS)2-(3-benzoylphenyl)-propionic acid | |
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(2R)-2-(3-phenylcarbonylphenyl)propanoic acid | |
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White crystalline solid |
Formulations |
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Curacef Duo Suspension for Injection | Virbac | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Dinalgen Solution for Injection | Ecuphar Veterinaria S.L.U. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Ketofen 1% solution for injection | Ceval Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Ketosan Solution for Injection | Interchemie werken De Adelaar BV | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as solutions or suspensions for injection |
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500 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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93 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
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glucuronic acid | - | - | - |
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Terrestrial ecotoxicology |
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62.4 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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General |
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High (class II) | - | - | ||||||||
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62.4 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Extensively metabolised and around 90% of metabolites eliminated in the urine | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible blood, kidneys, liver and gastrointestinal tract toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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ketoprofen | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |