Halothane |
Last updated: 18/05/2024 |
(Also known as: fluothane) |
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A potent inhaled anesthetic once used in veterinary medicine | |
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1951, first synthesised | |
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Used for inhalational anesthesia | |
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Horses; Domestic animals; Mammals; Birds; Reptiles |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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₂HBrClF₃ | |
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C(C(F)(F)F)(Cl)Br | |
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No data | |
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BCQZXOMGPXTTIC-UHFFFAOYSA-N | |
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InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H | |
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Yes |
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Common Name | Relationship | Link |
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halothane | - |
General status |
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Anesthesetic | |
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Halogenated alkane | |
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Synthetic | |
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Involves interactions with multiple receptor sites to interfere with synaptic transmission. | |
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[Potassium channel subfamily K member 3, Binder], [Potassium channel subfamily K member 9, Binder], [Calcium-activated potassium channel subunit alpha 1, Inhibitor], [Glutamate [NMDA] receptor subunit 3A, inhibitor], [Glutamate [NMDA] receptor subunit 3B, inhibitor], [Glutamate [NMDA] receptor subunit epsilon-1, inhibitor], [Glycine receptor subunit alpha-1, modulator], [Rhodopsin], [G protein-activated inward rectifier potassium channel 2, inhibitor], [G protein-activated inward rectifier potassium channel 1, inhibitor], [NADH-ubiquinone oxidoreductase chain 1, inhibitor], [Intermediate conductance calcium-activated potassium channel protein 4, inhibitor], [ ATP synthase delta chain, mitochondrial], [Calcium-transporting ATPase type 2C member 1], [Gamma-aminobutyric-acid (GABA) receptor subunit alpha-1], [Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit], [Neuropeptide S receptor] | |
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151-67-7 | |
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205-796-5 | |
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Nervous system: Anaesthetics | |
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QN01AB01 | |
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No | |
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197.38 | |
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2-bromo-2-chloro-1,1,1-trifluoroethane | |
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1,1,1-trifluoro-2-bromo-2-chloroethane | |
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Colourless volatile liquid |
Formulations |
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Halothane-Vet 100% Inhalation vapour, liquid | Merial Animal Health Ltd | Not licensed | Not licensed | ||||||
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4070 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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-118 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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50.2 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.00 X 1002 | Calculated | - | |||||||
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2.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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1.87 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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4.02 X 1007 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Highly volatile. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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bromide | - | Humans (Liver) | - | ||||
trifluoroacetic acid | - | Humans (Liver) | - |
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Terrestrial ecotoxicology |
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> 5680 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5680 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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29.0 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 129 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Human3 = Unverified data of known source |
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Mainly eliminated via the lungs | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Strong respiratory depressant May cause cardiac arrest, hypotension, respiratory arrest, cardiac arrhythmias, hyperpyrexia, shivering, nausea |
Handling issues |
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Non-flammable, highly volatile | |||
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Not listed (Not listed) | |||
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halothane | ||
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halotano | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |