Closantel |
Last updated: 19/01/2024 |
(Not known by any other names) |
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A salicylanilide anthelmintic and antiparasitic veterinary drug | |
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Used for the treatment and control of adult and immature flukes, nematodes and larval stages of some arthropods | |
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Sheep; Cattle |
Approval status |
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Approved | |
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Aprroved |
Chemical structure |
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Closantel is a chiral molecule. | |
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C₂₂H₁₄Cl₂I₂N₂O₂ | |
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CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2O)I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl | |
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JMPFSEBWVLAJKM-UHFFFAOYSA-N | |
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InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30) | |
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Yes |
General status |
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Anthelmintic, Antiparasitic, Insecticide, Acaricide | |
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Salicylanilide | |
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Synthetic | |
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Acts by uncoupling oxidative phosphorylation. | |
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57808-65-8 | |
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260-967-1 | |
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42574 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP54AA51 | |
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No | |
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Allowed substance (Table 1: Bovine, Ovine) | |
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663.08 | |
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rac-N-[5-chloro-4-[(R)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide | |
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(RS)-5'-chloro-4'-(4-chloro-a-cyanobenzyl)-3,5-diiodosalicyl-o-toluidide | |
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N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide | |
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White to yellowish-brown crystalline powder | |
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Formulations |
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Closamectin Solution for Injection | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Closamectin Solution for Injection | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Flukiver Oral Suspension | Elanco Europe Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Superverm Oral Suspension | Elanco Europe Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Available in a range of formulations including pour-ons, oral suspensions and solutions for injection |
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215 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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220 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.29 X 1008 | Calculated | - | |||||||
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8.11 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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3-monoiodoclosantel | - | Animal (faeces) | - | ||||
5-monoiodoclosantel | - | Animal (faeces) | - |
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Terrestrial ecotoxicology |
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262 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Aquatic ecotoxicology |
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2.5 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Anguilla anguilla3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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262 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Intramuscular LD₅₀ = 28.4 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 67.0 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Around 80% excreted in the faeces | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible lung and kidney toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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closantel | ||
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closantel | ||
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Record last updated: | 19/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |