Decoquinate |
Last updated: 20/03/2024 |
(Not known by any other names) |
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A quinoline veterinary drug for both antibiotic prophylaxis and therapy | |
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Current | |
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circa 1993, first registered in USA | |
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Used for the prevention and treatment of coccidiosis, mainly in calves and lambs | |
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Cattle; Sheep; Goats; Birds and poultry |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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None | |
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C₂₄H₃₅NO₅ | |
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CCCCCCCCCCOC1=C(C=C2C(=C1)C(=O)C(=CN2)C(=O)OCC)OCC | |
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No data | |
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JHAYEQICABJSTP-UHFFFAOYSA-N | |
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InChI=1S/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26) | |
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Yes |
General status |
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Coccidiostat, Antiparasitic, Medicinal drug, Feed additive | |
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Quinoline | |
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Synthetic | |
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Thought to disrupt electron transport in the mitochondrial cytochrome system of coccidia | |
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[Mitochondrial respiration, Inhibitor], [Electron transport, Inhibitor] | |
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18507-89-6 | |
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242-389-1 | |
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- | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals | |
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QP51AX14 | |
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No | |
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Allowed substance (Table 1: Bovine, Ovine) | |
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417.54 | |
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- | |
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6-decoxy-7-ethoxy-4-oxo-1H-quinoline-3-carboxylic acid ethyl ester | |
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ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate | |
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Not phytoxic | |
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- | |
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White or light yellow crystalline powder |
Formulations |
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Deccox 6% Premix for medicated feeding stuff, for sheep and cattle | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Deccox 60 mg/g Premix for medicated feeding stuff, for sheep and cattle | Alpharma (Belgium) BVBA | Not licensed | Not licensed | |||||||
Deccox Feed Additive | Alpharma (Norway) AS | Not licensed | Not licensed | |||||||
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Often formulated as a medicated pre-mix feed |
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0.122 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low | ||||||||
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244 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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517.9 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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267.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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6.31 X 1007 | Calculated | - | |||||||
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7.8 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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Substance may enter the environment via the urine and faeces of treated animals or by leaching from spilt medicated feed. |
Degradation |
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110 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Persistent | |||||||
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General literature gives soil DT₅₀ between 96 and 550 days depending on soil type | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-mobile | |||||||
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400000 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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-3.27 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 5000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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75000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Unknown species3 = Unverified data of known source |
Low | ||||||||
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> 1000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Eisenia foetida3 = Unverified data of known source |
Low | ||||||||
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> 100 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Wheat Mustard Mungbean3 = Unverified data of known source Biomass, EC₅₀ as g ha⁻¹ |
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Aquatic ecotoxicology |
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> 0.016 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss3 = Unverified data of known source |
High | ||||||||
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> 0.034 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
High | ||||||||
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0.035 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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16.3 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Chironomus riparius Larva3 = Unverified data of known source |
Low | ||||||||
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0.00007 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Pseudokirchneriella subcapitata3 = Unverified data of known source |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 5000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Excreted via urine and faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Inhalation of dust may cause shortness of breath, tightness of the chest, a sore throat May cause gastrointestinal irritation |
Handling issues |
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Powdered material may form explosive dust-air mixtures Hydrophobic |
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Environment: H413 | |||
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Not listed (Not listed) | |||
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Stable when stored in a cool, dry place |
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decoquinate | ||
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decoquinato | ||
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Record last updated: | 20/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |