Doxapram |
Last updated: 23/02/2024 |
(Also known as: stimulexin) |
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A diphenylmethane compound used as a general CNS stimulant in veterinary medicine | |
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Used mainly to stimulate respiration during and after general anaesthesia in veterinary medicine | |
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Dogs; Cats; Horses; Calves; Lambs; Pigs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₄H₃₀N₂O₂ | |
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CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4 | |
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No data | |
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XFDJYSQDBULQSI-UHFFFAOYSA-N | |
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InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3 | |
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Yes |
General status |
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Respiratory stimulant, Analeptic, Medicinal drug | |
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Diphenylmethane | |
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Synthetic | |
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Stimulates chemoreceptors in the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. | |
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[Potassium channel subfamily K member 3, Antagonist], [Potassium channel subfamily K member 9, Antagonist] | |
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309-29-5 | |
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206-216-3 | |
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Respiratory system; Other respiratory system products | |
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QR07AB01 | |
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No | |
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Allowed substance (Table 1: All mammalian food producing species) | |
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378.51 | |
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1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one | |
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1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone | |
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White crystalline powder |
Formulations |
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Dopram V Drops 20mg/ml oral drops, solution | Pfizer Ltd | Not licensed | Not licensed | ||||||
Dopram V injection 20mg/ml solution | Pfizer Ltd | Not licensed | Not licensed | |||||||
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0.03 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
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123 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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4.57 X 1003 | Calculated | - | |||||||
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3.66 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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260 | E3 E = Manufacturers safety data sheets Rat as HCl variant3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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260 | E3 E = Manufacturers safety data sheets Rat as HCl variant3 = Unverified data of known source |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 268 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Mainly excreted as metabolites in urine and in the bile within 24-48 hours | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause high blood pressure, panic attacks and tachycardia Brain toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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doxapram | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |