Atropine sulphate |
Last updated: 23/02/2024 |
(Also known as: atropine sulfate; atropa belladonna) |
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A plant alkaloid drug used as an antidote in the treatment of organophosphate insecticide poisoning | |
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Current | |
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1550 B.C. recognised as a toxin; 1833, first isolated; circa 1950s, first medical use | |
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Used to reduce salivation, bronchial secretions or intestinal peristalsis associated with colic or diarrhea, and as a preanesthetic adjuvant. | |
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Horses; Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₁₇H₂₃NO₃ | |
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CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3 | |
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RKUNBYITZUJHSG-UHFFFAOYSA-N | |
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InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3 | |
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Yes |
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Common Name | Relationship | Link |
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D,L-Atropine | Parent |
General status |
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Analgesic, Medicinal drug | |
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Plant alkaloid | |
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Natural | |
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An antagonist for the muscarinic acetylcholine receptor | |
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[Muscarinic acetylcholine receptor M1, Antagonist], [Muscarinic acetylcholine receptor M2, Antagonist], [Muscarinic acetylcholine receptor M3, Antagonist], [Muscarinic acetylcholine receptor M4, Antagonist], [Muscarinic acetylcholine receptor M5, Antagonist] | |
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55-48-1 | |
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200-235-0 | |
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3661 | |
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Alimentary tract & metabolism: Drugs for functional gastrointestinal disorders | |
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QA03BA01 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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289.4 | |
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[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate | |
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White granular powder |
Formulations |
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Atrocare 600 ug/ml Solution for Injection | Animalcare Ltd | Not licensed | Not licensed | ||||||
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3940 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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2380 | L3 L = Pesticide manuals and hard copy reference books / other sources Chloroform3 = Unverified data of known source |
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330 | L3 L = Pesticide manuals and hard copy reference books / other sources Ether3 = Unverified data of known source |
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400000 | l3 L = Pesticide manuals and hard copy reference books / other sources Glycerol3 = Unverified data of known source |
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190 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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8.13 X 1001 | Calculated | - | |||||||
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1.91 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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2.59 X 10-03 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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tropic acid | - | Mammals | - | ||||
tropine | - | Mammals | - |
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Terrestrial ecotoxicology |
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75 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
High | ||||||||
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Aquatic ecotoxicology |
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258 | R3 R = Peer reviewed scientific publications Daphnia magna 24 hr3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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75 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
High | ||||||||
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Subcutaneous LD₅₀ = 540 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 37 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Approx. 50% hydrolysed and 50% excreted unchanged in urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Highly toxic to lungs, the nervous system and mucous membranes May cause nausea or vomiting May cause confusion and nervousness |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Health: H300, H330 | |||
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Not listed (Not listed) | |||
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UN1544 | |||
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Packaging Group II (moderate danger) | |||
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atropine sulphate | ||
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sulfate d'atropine | ||
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Atropinsulfat | ||
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atropiny siarczan | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |