Metoclopramide |
Last updated: 14/01/2024 |
(Also known as: metochlopramide; methochlopramide) |
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Metoclopramide is a dopamine receptor antagonist used in veterinary medicine | |
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Current | |
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1964, discovered | |
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Used to treat nausea and vomiting associated with conditions such as emetogenic drugs, uremia, radiation sickness, malignancy, labour and infection. | |
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Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₄H₂₂ClN₃O₂ | |
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CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl | |
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No data | |
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TTWJBBZEZQICBI-UHFFFAOYSA-N | |
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InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19) | |
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Yes |
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Common Name | Relationship | Link |
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metoclopramide | - |
General status |
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Antiemetics, Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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Binds to dopamine D2 receptors where it is a receptor antagonist. Stimulates the muscles of the gastrointestinal tract. | |
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[D(2) dopamine receptor, Antagonist], [Muscarinic acetylcholine receptor M1, Agonist], [5-hydroxytryptamine 4 receptor, Agonist] | |
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364-62-5 | |
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206-662-9 | |
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Alimentary tract & metabolism: Propulsives | |
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QA03FA01 | |
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No | |
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299.80 | |
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4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | |
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2-methoxy-5-chloroprocainamide | |
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Evidence of use in third world countries | |
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Solid |
Formulations |
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Emeprid 1 mg/ml oral solution for dogs and cats | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Metomotyl Solution for Injection | Le Vet Beheer B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Vomend 5 mg/ml oral solution for dogs and cats | Eurovet Aninmal Health B.V | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Often formulated as solutions for injection or for oral administration |
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200 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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23000 | L3 L = Pesticide manuals and hard copy reference books / other sources Ethanol3 = Unverified data of known source |
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19000 | L3 L = Pesticide manuals and hard copy reference books / other sources Ethanol3 = Unverified data of known source |
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1000 | L3 L = Pesticide manuals and hard copy reference books / other sources Benzene3 = Unverified data of known source |
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66000 | L3 L = Pesticide manuals and hard copy reference books / other sources Chloroform3 = Unverified data of known source |
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146 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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4.17 X 1002 | Calculated | - | |||||||
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2.62 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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9.27 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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6.13 X 10-04 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 280 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 280 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Moderate | ||||||||
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Subcutaneous LD₅₀ = 340 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 50 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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The elimination of metoclopramide is rapid, 65 % of the dose being eliminated within 24 hours in the dog, primarily by the urinary route | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause confusion, mood changes and decreased coordination May cause energy loss, diarrhoea, dizziness, drowsiness, headache and nausea |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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metoclopramide | ||
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metoclopramida | ||
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Record last updated: | 14/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |