Ceftiofur |
Last updated: 31/05/2024 |
(Not known by any other names) |
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Broad spectrum third generation cephalosporin drug used to treat bacterial infections of the respiratory tract. It is often formulated using the hydrochloride salt. | |
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Current | |
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1987, first described | |
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Typically used to treat bovine respiratory disease caused by Pasteurella spp. and for urinary tract infections in dogs | |
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Cattle; Pigs; Horses; Goats; Chickens; Turkeys |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₉H₁₇N₅O₇S₃ | |
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CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CSC(=O)C4=CC=CO4)C(=O)O | |
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CO/N=C(\C1=CSC(=N1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)CSC(=O)C4=CC=CO4)C(=O)O | |
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ZBHXIWJRIFEVQY-IHMPYVIRSA-N | |
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InChI=1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1 | |
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Yes |
General status |
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Antibacterial, Antibiotic, Medicinal drug | |
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Cephalosporin | |
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Semi-synthetic | |
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Inhibition of the bacteria cell wall synthesis | |
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[Beta-lactamase, Agonist] | |
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80370-57-6 | |
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6328657 | |
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Antiinfectants for systemic use: Antibacterials for systemic use, Antibacterials for intramammary use | |
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QJ01DD90; QJ51DA91 | |
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No | |
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Allowed substance (Table 1: All mammalian food producing species) | |
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523.56 | |
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(6R,7R)-7-[ [(2Z)-2-(2-amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
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3-[(2-furylcarbonyl)thio]methyl]-7-[2-(2-amino-4-thiazolyl)-2- (methoxyiminoacetamido)-3-cephem-4-carboxylic acid | |
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Solid | |
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Formulations |
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Usually formulated, using the hydrochloride salt, as a solution for injection |
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249 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Moderate | ||||||||
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3.47 X 1000 | Calculated | - | |||||||
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0.54 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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2.62 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Absorb at wavelengths >290nm | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Environmental release may occur via direct deposition of faeces and urine in the field from treated animals or via the spreading of manures and slurry. |
Degradation |
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37.5 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately persistent | |||||||
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37.5 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately persistent | ||||||||
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General literature values: in clay loam at pH 5 DT₅₀ 22.2 days; sand at pH 7 DT₅₀ 49 days; silty clay loam at pH 9 DT₅₀ 41.1 days; Other studies DT₅₀ range 0.76-4.31 days | ||||||||||
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1.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) In poultry litter DT₅₀ for ceftiofur was 25 hours; Other data DT₅₀ 1.7-41 days3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 1 = Estimated data with little or no verification |
Slightly mobile | |||||||
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3700 | ||||||||||
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Estimated | ||||||||||
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90.0 | - | - | |||||||
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Literature data Kf range 57.63-122.44 μg l⁻¹ | ||||||||||
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Fate indices |
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0.68 | Calculated | Low leachability | ||||||||||||||||||||||||||
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3.0 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Not available | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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desfuroylceftiofur | DFC | Rat (Urine) | - | ||||
ceftiofur sulfoxide | - | Rat (Urine) | - | ||||
desfuroylceftiofur | - | Cattle | - |
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Terrestrial ecotoxicology |
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> 7760 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 7760 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 8.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat 4 hr3 = Unverified data of known source |
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May occur through dermal contact | ||||||||||
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Rapidly metabolised and eliminated, 60-80% with urine, remainder in faeces | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause diarrhoea, colitis, depression in body-weight gain and in serum glucose, and acidification of urine |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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Shelf-life as packaged for sale: 3 years. Store in a refrigerator (2ºC - 8ºC) and protect from light. |
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ceftiofur | ||
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Record last updated: | 31/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |