Thiamazole |
Last updated: 18/05/2024 |
(Also known as: methimazole; tapazole; dibazol; methylmercaptoimidazole ) |
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An antithyroid veterinary medication and chemical degradation product of carbimazole | |
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Current | |
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1949, developed | |
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Used for the stabilisation and treatment of hyperthyroidism | |
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Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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- | |
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C₄H₆N₂S | |
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CN1C=CNC1=S | |
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No data | |
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PMRYVIKBURPHAH-UHFFFAOYSA-N | |
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InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7) | |
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Yes |
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Common Name | Relationship | Link |
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thiamazole | - |
General status |
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Antithyroid drug, Medicinal drug | |
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Human, Animal | |
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Thioamide | |
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Synthetic | |
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Inhibits the addition of iodine to thyroglobulin by the enzyme thyroperoxidase | |
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[Thyroperoxidase, Inhibitor] | |
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60-56-0 | |
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200-482-4 | |
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Systemic hormonal preparations:Thyroid therapy: Sulphur-containing imidazole derivatives | |
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QH03BB02 | |
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No | |
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114.17 | |
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1-methyl-3H-imidazole-2-thione | |
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1-methyl-1,3-dihydroimidazole-2-thione | |
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Beige coloured, odourous powder |
Formulations |
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Felimazole 2.5mg Coated Tablets for Cats | Dechra Ltd | Not licensed | Not licensed | ||||||
Felimazole 5mg Coated Tablets for Cats | Dechra Ltd | Not licensed | Not licensed | |||||||
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2.75 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low | ||||||||
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8000 | E3 E = Manufacturers safety data sheets Ether3 = Unverified data of known source |
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220000 | E3 E = Manufacturers safety data sheets Chloroform3 = Unverified data of known source |
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200000 | E3 E = Manufacturers safety data sheets Methanol3 = Unverified data of known source |
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146 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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155 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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280 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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47 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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5.01 X 10-01 | Calculated | - | |||||||
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-0.3 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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1.36 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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glucuronide | - | Animals (Urine) | - |
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Terrestrial ecotoxicology |
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> 2250 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2250 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ = 1050 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 500 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Some metabolism, parent and metabolites excreted in urine and faeces | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause joint and muscle pain, drowsiness or dizziness Possible blood, liver, endocrine and thyroid toxicant |
Handling issues |
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Slightly flammable Emits toxic fumes of nitroxides and sulfoxides in a fire Risk of dust explosion |
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Health: H302, H317, H319, H361 | |||
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Not listed (Not listed) | |||
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thiamazole | ||
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thiamazol | ||
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tiamazol | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |