Omeprazole |
Last updated: 27/04/2024 |
(Not known by any other names) |
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Human and veterinary proton-pump inhibiting drug for suppressing stomach acid secretion | |
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Current | |
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1989, first marketed | |
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Used for treating acid-induced inflammation and ulcers of the stomach and duodenum and to prevent gastric bleeding. The drug also has some antibiotic action and may be used to treat stomach infectons. | |
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Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₇H₁₉N₃₀₃S | |
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CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC | |
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SUBDBMMJDZJVOS-UHFFFAOYSA-N | |
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InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20) | |
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Yes |
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Common Name | Relationship | Link |
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omeprazole | - | |
omeprazole | Racemate |
General status |
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Medicinal drug, Antibiotic | |
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Unclassified substance | |
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Synthetic | |
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Selective and irreversible proton pump inhibitor, inhibits gastric acid secretion | |
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[Potassium-transporting ATPase alpha chain 1, Antagonist] | |
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73590-58-6 | |
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Alimentary tract & metabolism: Drugs for acid related disorders | |
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QA02BC01 | |
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No | |
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Allowed substance (Table 1: Equidae) | |
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345.42 | |
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(RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1H-benzo[d]imidazole | |
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5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole | |
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White powder |
Formulations |
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Bimeprazol Oral Paste | Bimeda Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Equizol Gastro-Resistant Granules | CP Pharma Handelsgesellschaft mbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Peptizole Oral Paste | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Ulcergold oral paste | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated for oral administreation such as tablets and oral pastes |
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82.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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156 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.58 X 1002 | Calculated | - | |||||||
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2.2 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low | ||||||||
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1.22 X 10-07 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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omeproazole sulfone | - | Human (Liver) | - | ||||
omeprazole sulfide | - | Human (Liver) | - | ||||
5-hydroxyomeprazole | - | Human (Liver) | - | ||||
5-O-desmethylomeprazole | - | Human (Liver) | - |
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Terrestrial ecotoxicology |
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> 2210 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2210 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ > 100 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ > 100 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Metabolised in the liver with ~80% being excreted as metabolites in the urine, remainder is lost in faeces and bile. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause headache, diarrhoea, abdominal pain, nausea and dizziness May increase risk of hip fracture |
Handling issues |
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Hygroscopic and photosensitive | |||
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Not listed (Not listed) | |||
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omeprazole | ||
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omeprazol | ||
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Record last updated: | 27/04/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |