Sulphadimidine |
Last updated: 23/02/2024 |
(Also known as: sulfadimidine; sulfamethazine) |
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A Ssulfonamide drug used in veterinary medicine often in combination with chlortetracycline and penicillin | |
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Current | |
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1941, first reported | |
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Multiple uses including for the treatment of bovine respiratory disease, calf diphtheria, bacterial pneumonia and procine colibacillosis as wel as coccidiosis, fowl cholera and pullorum disease. | |
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Pigs; Fowl; Cattle; Sheep |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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- | |
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C₁₂H₁₄N₄O₂S | |
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CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C | |
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No data | |
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ASWVTGNCAZCNNR-UHFFFAOYSA-N | |
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InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16) | |
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Yes |
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Common Name | Relationship | Link |
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sulphadimidine | - |
General status |
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Antibacterial, Anti-infective, Antibiotic, Antimicrobial, Medicinal drug | |
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Sulfonamide | |
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Synthetic | |
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A competitive inhibitor of dihydropteroate synthase | |
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[Dihydropteroate synthetase, Antagonist] | |
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57-68-1 | |
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200-346-4 | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals; Antiinfectants for systemic use: Antibacterials for systemic use | |
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QP51AG01; QJ01EQ | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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278.33 | |
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- | |
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4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | |
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4,6-dimethyl-2-sulfanilamidopyrimidine | |
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- | |
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Possible groundwater contaminant | |
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White crystalline powder |
Formulations |
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Intradine 30.89% w/v Solution for Injection | Norbrook Laboratories Ltd | Not licensed | Not licensed | ||||||
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Often supplied as a solution for injection or a solution for oral administration |
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1500 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) at 29 °C5 = Verified data used for regulatory purposes |
High | ||||||||
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198.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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452 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
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1.55 X 1000 | Calculated | - | |||||||
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0.19 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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7.59 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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9.09 X 10-04 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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3.09 X 10-11 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-volatile | ||||||||
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Acidic: max at 241nm and 297nm Neutral: max at 241nm Basic: max at 243nm and 257nm |
V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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15044 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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18.6 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-persistent | |||||||
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General literature suggests biodegradation may be slow in some soils. | ||||||||||
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- | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Hydolysis not expected | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately mobile | |||||||
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115.3 | ||||||||||
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General literature Kd range 0.9-3.5 mL g⁻¹, Koc values range 61-170 mL g⁻¹ | ||||||||||
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Fate indices |
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2.46 | Calculated | Transition state | ||||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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N4-acetylated sulfonamide | - | Human (Liver) | - |
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Terrestrial ecotoxicology |
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> 2000 | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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> 100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oryzias latipes5 = Verified data used for regulatory purposes |
Low | ||||||||
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31.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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8.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pseudokirchneriella subcapitata as IC505 = Verified data used for regulatory purposes |
Moderate | ||||||||
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1.0 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pseudokirchneriella subcapitata 72 hr EC104 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2000 | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 2450 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rabbit3 = Unverified data of known source |
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Partly metabolibised and eliminated predominately in urine with lesser amounts in faeces, bile and milk. | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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Harmful if inhaled may cause gastric irritation and vomiting Possible liver and kidney toxicant Some published studies suggest substance is carcinogenic |
Handling issues |
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Light sensitive Not explosive or oxidising |
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Health: H315, H319 | |||
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Not listed (Not listed) | |||
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sulphadimidine | ||
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sulfametazina | ||
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sulfadimidina | ||
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sulfametazina | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |