Norfloxacin |
Last updated: 18/05/2024 |
(Not known by any other names) |
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Broad spectrum antiobiotic drug active against both gram-positive and gram-negative bacteria | |
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1979, first patent | |
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Mainly used to treat urinary tract, respiratory and other infectious diseases | |
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Sheep; Pigs; Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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- | |
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C₁₆H₁₈FN₃O₃ | |
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CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O | |
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No data | |
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OGJPXUAPXNRGGI-UHFFFAOYSA-N | |
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InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23) | |
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Yes |
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Common Name | Relationship | Link |
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norfloxacin | - |
General status |
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Antibiotic, Antibacterial, Chemotherapy drug, Medicinal drug | |
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Fluoroquinolone | |
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Synthetic | |
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Inhibits bacterial DNA gyrase | |
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[DNA topoisomerase 4 subunit A, Antagonist], [DNA gyrase subunit A, Antagonist], [DNA topoisomerase 2-alpha, Antagonist] | |
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70458-96-7 | |
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274-614-4 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01MA06 | |
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No | |
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319.33 | |
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1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylic acid | |
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1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid | |
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Evidence of use in third world countries | |
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White to pale yellow crystalline powder |
Formulations |
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178000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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980 | L3 L = Pesticide manuals and hard copy reference books / other sources Methanol3 = Unverified data of known source |
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1900 | L3 L = Pesticide manuals and hard copy reference books / other sources Ethanol3 = Unverified data of known source |
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5100 | L3 L = Pesticide manuals and hard copy reference books / other sources Acetone3 = Unverified data of known source |
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5500 | L3 L = Pesticide manuals and hard copy reference books / other sources Chloroform3 = Unverified data of known source |
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227 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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8.51 X 1000 | Calculated | - | |||||||
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0.93 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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6.26 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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pKa(2) = 8.75 | |||||||||||
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9.00 X 10-08 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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In NaOH: 274nm, 325nm, 336nm | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 4000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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> 2 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia LC₅₀4 = Verified data |
Moderate | ||||||||
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16.6 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Low | ||||||||
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4.01 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 4000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ > 1500 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 245 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Eliminated through metabolism, biliary excretion, and renal excretion. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Possible kidney, liver and renal toxicant |
Handling issues |
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Hygroscopic in air | |||
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Not listed (Not listed) | |||
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norfloxacin | ||
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norfloxacine | ||
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norfloxacino | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |