Valnemulin |
Last updated: 23/02/2024 |
(Not known by any other names) |
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A semi-synthetic pleuromutilin derivative antimicrobial veterinary drug | |
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Current | |
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1999, first introduced veterinary medicince | |
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Used to treat dysentery, ileitis, coliti pneumonia and intestinal infections | |
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Pigs; Cattle; Rabbits |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₃₁H₅₂N₂O₅S | |
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CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC(C)(C)CNC(=O)C(C(C)C)N)C | |
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C[C@@H]1CCC23CCC(=O)[C@H]2C1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC(C)(C)CNC(=O)[C@@H](C(C)C)N)C | |
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LLYYNOVSVPBRGV-FMWPFBIJSA-N | |
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InChI=1S/C31H52N2O5S/c1-10-29(8)15-22(38-23(35)16-39-28(6,7)17-33-27(37)24(32)18(2)3)30(9)19(4)11-13-31(20(5)26(29)36)14-12-21(34)25(30)31/h10,18-20,22,24-26,36H,1,11-17,32H2,2-9H3,(H,33,37)/t19-,20+,22-,24-,25+,26+,29-,30+,31+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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valnemulin hydrochloride dihydrate | Varinant |
General status |
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Antibiotic, Antibacterial, Medicinal drug, Medicated feed additive | |
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Pleuromutilin derivative | |
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Semi-synthetic | |
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Protein synthesis inhibitor at the bacterial ribosome level | |
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[50S rRNA, Antagonist] | |
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101312-92-9 | |
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9850878 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01XQ02 | |
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No | |
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Allowed substance (Table 1: Porcine, Rabbit) | |
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564.81 | |
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- | |
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[(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[1-[[(2R)-2-amino-3-methylbutanoyl]amino]-2-methylpropan-2-yl]sulfanylacetate | |
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acetic acid, 2-[[2-[[(2R)-2-amino-3-methyl-1-oxobutyl]amino]-1,1-dimethylethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester | |
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Off-white coloured solid | |
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Formulations |
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Econor Oral Powder | Elanco GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Econor premix medicated feed | Elanco GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually supplied as an oral solution or as a medicated premix feed |
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141 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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a: 49-590 days; b: 13-73 days | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) temp dependant a=slurry b=soil/slurry 5 = Verified data used for regulatory purposes |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Moderately mobile | |||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 1000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 1000 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) predicted3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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> 28.2 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Predicted3 = Unverified data of known source |
Moderate | ||||||||
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> 15 | R3 R = Peer reviewed scientific publications Seriola lalandi 28 day3 = Unverified data of known source |
Low | ||||||||
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44.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 2.3 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) estimated3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Extensively metabolised, metabolites excreted in bile | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Liver toxicant May cause weight loss |
Handling issues |
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no information available | |||
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Not listed (Not listed) | |||
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valnemulin | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |