Cefoperazone |
Last updated: 12/01/2024 |
(Also known as: cephoperazone) |
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A broad spectrum antibiotic used against gram-positive, gram-negative and anaerobic bacteria | |
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Used to treat bacterial infections including those affecting the respiratory tract, abdomen, skin, and female genital tracts. Also used to manage clinical mastitis in lactating cows | |
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Cattle; Horses; Sheep |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₂₅H₂₇N₉O₈S₂ | |
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CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O | |
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CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)O | |
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GCFBRXLSHGKWDP-XCGNWRKASA-N | |
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InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Medicinal drug | |
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Cephalosporin | |
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Semi-synthetic | |
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Broad spectrum, inhibits bacterial cell wall synthesis | |
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[Peptidoglycan synthetase ftsI, Antagonist], [Penicillin-binding protein 1B, Antagonist], [Penicillin-binding protein 2, Antagonist], [Penicillin-binding protein 1A, Antagonist], [Penicillin-binding protein 1B, Antagonist], [D-alanyl-D-alanine carboxypeptidase dacC, Antagonist], [Penicillin-binding protein 1A, Antagonist], [Penicillin-binding protein 5 precursor, Antagonist], [Penicillin-binding protein 4, Antagonist] | |
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62893-19-0 | |
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263-749-4 | |
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44187 | |
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Antiinfectants for systemic use: Antibacterials for intramammary | |
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QJ51DA32 | |
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No | |
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Allowed substance (Table 1: Bovine) | |
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645.67 | |
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(6R,7S)-7-{[2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl}amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
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Solid |
Formulations |
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Pathocef 250 mg Intramammary Suspension | Zoetis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Often formulated as an intramammary suspension liquid |
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64.2 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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169 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.82 X 10-01 | Calculated | - | |||||||
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-0.74 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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1.28 X 10-24 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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Ref: T-1551-A | - | Rat (Urine, Bile) | - | ||||
Ref: T-1551-D | - | Rat (Faeces) | - | ||||
Ref: T-1551-F | - | Rat (Urine, Bile) | - |
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Terrestrial ecotoxicology |
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> 15000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 15000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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In rats paranteral administration led to excretion mainly in the bile with little metabolism. However with rabbits, dogs and mokey the majority is lost in the urine. Oral administration leads to excretion in the faeces. | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Harmful by skin contact and inhalation Possible blood toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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cefoperazone | ||
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cefoperazono | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |