Doxycycline |
Last updated: 09/02/2024 |
(Also known as: vibramycin-D; doxytetracycline) |
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A tetracycline antibiotic drug effective against a broad range of gram-positive and gram-negative bacteria. It is often used as the hyclate variant. | |
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Current | |
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early 1960s, developed | |
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Used to treat bacterial infections including pneumonia and other respiratory tract infections | |
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Dogs; Cats; Pigs; Chickens; Birds |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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₂₂H₂₄N₂O₈ | |
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CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O | |
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C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O | |
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JBIWCJUYHHGXTC-AKNGSSGZSA-N | |
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InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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doxycycline monohydrate | Hydrate |
General status |
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Antibiotic, Antiparasitic, Antiprotozoal, Antibacterial, Medicinal drug | |
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Tetracycline | |
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Synthetic | |
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A protein synthesis inhibitor | |
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[30S ribosomal protein S9, Antagonist], [30S ribosomal protein S4, Antagonist], [16S rRNA, Antagonist] | |
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564-25-0 | |
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209-271-1 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01AA02 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine, Poultry) | |
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444.44 | |
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(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide | |
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α-6-deoxy-5-hydroxytetracycline | |
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Yellow crystalline powder | |
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Formulations |
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Doxipulvis Powder for Drinking Water | SP Veterinaria S.A. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Doxybactin | Dechra Regultory BV | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Doxycare Flavour Tablets | Ecuphar NV | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available as powders for adding to drinking water and tablets for oral administration |
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630 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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201 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Chars without melting3 = Unverified data of known source |
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9.55 X 10-01 | Calculated | - | |||||||
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-0.02 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.89 X 10-18 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Max in 0.01 N Methanolic hydrogen chloride: 267nm LOG E= 4.24, 351nm LOG E= 4.12 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intravenous LD₅₀ = 228 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 378 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) rat3 = Unverified data of known source |
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Largely metabolised and excreted in the faeces (20-40%) and urine (20-30%) | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause photosensitivity skin reactions May cause nausea and vomiting |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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doxycycline | ||
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doxiciclina | ||
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doxiciclina | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |