Tricaine mesylate |
Last updated: 13/01/2024 |
(Also known as: tricaine methane sulphonate; tricaine methane sulfonate; MS222; TMS; tricaine mesilate) |
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A veterinary anesthetic agent used for aquatic species | |
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Current | |
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Used for anesthesia, sedation or euthanasia of fish | |
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Fish |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₀H₁₅NO₅S | |
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CCOC(=O)C1=CC(=CC=C1)N.CS(=O)(=O)O | |
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No data | |
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FQZJYWMRQDKBQN-UHFFFAOYSA-N | |
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InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4) | |
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General status |
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Anesthetic, Muscle relaxant, Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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Acts by preventing action potentials and so as no signals care exchanged between the brain and the extremities organs cease to operate | |
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886-86-2 | |
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212-956-8 | |
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Nervous system: Anesthetics | |
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QN01AX93 | |
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No | |
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Allowed substance (Table 1: Fin fish) | |
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261.30 | |
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ethyl 3-aminobenzoate methanesulfonic acid | |
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ethyl-m-aminobenzoate methanesulfonate | |
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Fine, white, odourless crystalline powder |
Formulations |
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Nytox Powder | Virbac | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Syncaine Powder | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | Tricaine Powder | |||||||
Pharmaq Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | - | |||||||
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Usually supplied in powder form |
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149.5 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 5200 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5200 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Intravenous LD₅₀ > 180 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Can be absorbed through the skin | ||||||||||
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In fish it is rapidly metabolised primarily by the liver but also in the kidneys, blood, metabolites then are excreted through the gills and liver | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause skin irritation, resulting in reddening, itching, and inflammation |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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tricaine mesylate | ||
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Record last updated: | 13/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |