Benzoyl peroxide |
Last updated: 18/05/2024 |
(Also known as: diphenylglyoxal peroxide; benzoyl superoxide; benzoic acid peroxide) |
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A topically applied antibacterial and anti-inflammatory agent | |
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Current | |
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1929, first used for wounds | |
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Used as an antibacterial agent to treat burns and as a dermatologic agent for skin infections and rashes | |
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Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₄H₁₀O₄ | |
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C1=CC=C(C=C1)C(=O)OOC(=O)C2=CC=CC=C2 | |
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No data | |
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OMPJBNCRMGITSC-UHFFFAOYSA-N | |
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InChI=1S/C14H10O4/c15-13(11-7-3-1-4-8-11)17-18-14(16)12-9-5-2-6-10-12/h1-10H | |
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Yes |
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Common Name | Relationship | Link |
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benzoyl peroxide | - |
General status |
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Antibacterial, Antibiotic | |
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Substituted benzene | |
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Synthetic | |
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Metabolises and so generates free radicals that oxidise proteins in bacterial cell membranes, exerting a bactericidal action. | |
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[Catalase, Inhibitor], [Glutathione peroxidase, Inhibitor], [Arginine decarboxylase, Activator], [Protein kinase C, Inhibitor], [Superoxide Dismutases, Inhibitor] | |
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94-36-0 | |
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202-327-6 | |
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Dermatologicals: Other dermatological preparations | |
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QD11AX90 | |
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No | |
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242.23 | |
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dibenzoyl peroxide | |
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benzoyl peroxide | |
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White solid |
Formulations |
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Paxcutol 2.5875 % w/v Shampoo | Virbac | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Often supplied as shampoos and pour-on formulations |
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9.1 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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250000 | L3 L = Pesticide manuals and hard copy reference books / other sources Carbon disulphide3 = Unverified data of known source |
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104 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Explodes before boiling | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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176 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Autoignition3 = Unverified data of known source |
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2.88 X 1003 | Calculated | - | |||||||
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3.46 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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1.334 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.543 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 1 = Estimated data with little or no verification |
Slightly mobile | |||||||
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1800 | ||||||||||
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Estimated | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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benzoic acid | - | Animals | - |
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Terrestrial ecotoxicology |
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> 7710 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 7710 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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1000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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12.2 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 250 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Excreted as the benzoate in the urine | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Moderately toxic May cause blindness |
Handling issues |
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Potentially explosive, strong oxidant and highly flammable Corrosive IMDG Transport Hazard Class 5.2 |
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Not listed (Not listed) | |||
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UN3104 | |||
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Packaging Group II (moderate danger) | |||
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benzoyl peroxide | ||
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peroxyde de benzoyle | ||
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Benzoylperoxid | ||
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perossido di benzoile | ||
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benzoylperoxyde | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |