Fluoxetine (Ref: LY-110140) |
Last updated: 23/08/2024 |
(Also known as: Prozac) |
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Fluoxetine is an SSRI antidepressant used in veterinary medicine | |
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Current | |
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circa 1970 discovered; 1977 introduced to market | |
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Used to treat behavioural problems, including aggression and obsessive compulsive behaviour | |
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Cats; Dogs; Caged birds |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Fluoxetine has a chiral center giving two enantiomers, R-fluoxetine and S-fluoxetine. The two enantiomers of fluoxetine are similarly effective in blocking serotonin reuptake. Technical materrial is an isomeric mixture. | |
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C₁₇H₁₈F₃NO | |
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CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F | |
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No data | |
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RTHCYVBBDHJXIQ-UHFFFAOYSA-N | |
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InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 | |
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Yes |
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Common Name | Relationship | Link |
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fluoxetine oxalate | Variant |
General status |
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Antidepressant, Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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Selective serotinin reuptake inhibitor (SSRI) Class | |
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[Sodium-dependent serotonin transporter, Antagonist], [ 5-hydroxytryptamine 2A receptor, Antagonist] | |
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54910-89-3 | |
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Nervous system: Psychoanaleptics | |
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QN06AB03 | |
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No | |
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309.33 | |
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N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine | |
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N-methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine | |
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Marine pollutant | |
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White crystalline solid |
Formulations |
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Reconcile Chewable tablets for dogs | Forte Healthcare Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually supplied in tablet form |
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60.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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180 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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3.98 X 1004 | Calculated | - | |||||||
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4.6 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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8.7 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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para-trifluoromethylphenol | - | Human (Liver) | - | ||||
norfluoxetine | - | Human (Liver) | - |
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Terrestrial ecotoxicology |
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825 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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0.200 | R4 R = Peer reviewed scientific publications Pimephales promelas4 = Verified data |
Moderate | ||||||||
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0.94 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
Moderate | ||||||||
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> 0.38 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia LC₅₀4 = Verified data |
Moderate | ||||||||
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0.500 | R4 R = Peer reviewed scientific publications Americamysis bahia4 = Verified data |
Moderate | ||||||||
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0.031 | E3 E = Manufacturers safety data sheets Green algae3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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825 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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500 | E4 E = Manufacturers safety data sheets Rabbit4 = Verified data |
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Intraperitoneal LD₅₀ = 87.5 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Extensively metabolised in the liver and excreted in the urine and also identified in breast milk | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause sexual dysfunction Possible liver toxicant May cause drowsiness, tremor, headache, dizziness and blurred vision May cause nausea, vomiting and abdominal pain |
Handling issues |
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Oxidising agent IMDG Transport Hazard Class 9 |
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Not listed (Not listed) | |||
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UN3077 | |||
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Packaging Group III (minor danger) | |||
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fluoxetine | ||
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fluoxetine | ||
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Fluoxetin | ||
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fluoxetin | ||
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fluoxetina | ||
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fluoxetina | ||
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- | ||
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fluoksetyna | ||
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fluoxetin | ||
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fluoxetin | ||
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fluoxetine | ||
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Record last updated: | 23/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |