Betamethasone |
Last updated: 20/01/2024 |
(Also known as: betadexamethasone; betafluorene) |
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A glucocorticoid drug which exhibits anti-inflammatory and immunosuppressant properties | |
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Current | |
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1985, patented; 1961 first medical approvals | |
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Mainly used to treat a variety of conditions including skin irritations and infections, allergic reactions, arthritis, breathing disorders | |
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Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₂₂H₂₉FO₅ | |
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CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C | |
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C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C | |
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UREBDLICKHMUKA-DVTGEIKXSA-N | |
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InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 | |
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Yes |
General status |
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Anti-inflammatory, Immunosuppressant | |
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Corticosteroid | |
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Synthetic | |
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Modifies the levels and array of proteins synthesised by the various target tissues | |
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[Glucocorticoid receptor, Agonist] | |
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378-44-9 | |
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206-825-4 | |
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Dermatologicals: Corticosteriods, dermatological preparations; Systemic hormone preparations excluding sex hormones & insulin: Corticosteroids for systemic use; Sensory organs: Otologicals | |
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QD07CC01; QH02AB01; QS02CA90 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine) | |
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392.46 | |
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(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one | |
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1-dehydro-9-fluoro-17-hydroxy-16β-methyl-corticosterone | |
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Cream coloured crystalline powder | |
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Formulations |
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Betafuse gel | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Fuselieve Gel | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Otomax Ear Drops Suspension | MSD Animal Health UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Often formulated as gels for topical use or as a solution with dropper for ear conditions |
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65.5 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Moderate | ||||||||
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160000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Methanol3 = Unverified data of known source |
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235.6 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
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Decomposes before boiling | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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232 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.02 X 1002 | Calculated | - | |||||||
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2.01 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Low | ||||||||
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13.48 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Methanol: 238nm = 15200 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 4500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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> 20 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 4500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Low | ||||||||
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Metabolised end excreted in the urine | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause perioral or allergic contact dermatitis |
Handling issues |
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No information available | |||
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Health: H360, H373 | |||
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Not listed (Not listed) | |||
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betamethasone | ||
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betametasona | ||
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Record last updated: | 20/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |