Tilmicosin |
Last updated: 20/03/2024 |
(Also known as: 20-deoxy-20-(3,5-dimethylpiperidin-1-yl)-desmycosin ; AH0230 / AH0470; tilmicosina) |
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A semi-synthetic macrolide antibiotic | |
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Current | |
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- | |
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Used for the treatment and prevention of pneumonia associated with Pasteurella haemolytica, P. multocida, Actinobacillus pleuropneumoniae, mycoplasma species and other microorganisms | |
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Cattle; Sheep; Pigs; Poultry; Rabbits; Fish |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric - available in both the cis- and trans-forms | |
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C₄₆H₈₀N₂O₁₃ | |
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CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)C)COC4C(C(C(C(O4)C)O)OC)OC | |
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CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H](C(CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC | |
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JTSDBFGMPLKDCD-SWSPHLSKSA-N | |
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InChI=1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Antimicrobial, Medicinal drug, Medicated feed additive | |
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Macrolide | |
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Semi-synthetic | |
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Interferes with protein synthesis | |
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[50S rRNA, Antagonist] | |
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108050-54-0 | |
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5282521 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01FA91 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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869.15 | |
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- | |
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(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3R,5S)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione | |
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4A-O-de(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxy-20-(3,5-dimethyl-1-piperidinyl)-(20(cis: trans)) tylosin | |
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Formulations |
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Apotil Solution for Injection | Nimrod Veterinary Products Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Hymantil solution for injection | Industrial Veterinaria S.A. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Tilmovet Oral Granules | Huvepharma N.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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A wide variety of formulations are available including solutions for injection, granules and premixed medicated feeds |
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566000 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
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107 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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1.23 X 1005 | Calculated | - | |||||||
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5.09 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
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13.16 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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UV max: 283nm = 22643 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Substance may enter the environment via the faeces of treated animals or by leaching from spilt medicated feed. |
Degradation |
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64 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Moderately persistent | |||||||
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730 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Very persistent | ||||||||
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USEPA data: suggests soil DT₅₀ >2 years; Literature variable & sparse (i) 45.9% decline in loam soil after 1 year, no decline in clay loam after 1 year (E3); (ii) >64 days (R3) | ||||||||||
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0.82 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Fast | |||||||
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Not pH sensitive | ||||||||||
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Stable | E4 E = Manufacturers safety data sheets 4 = Verified data |
Stable | |||||||
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Stable at pH 5 & 7, DT₅₀ 156 days at pH 9 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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178.5 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-mobile | |||||||
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16319 | ||||||||||
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USEPA data: Kd range 86-318 mL g⁻¹, Koc range 4244-36150 mL g⁻¹, Soils=4 | ||||||||||
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Fate indices |
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-0.61 | Calculated | Low leachability | ||||||||||||||||||||||||||
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450 | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Estimated1 = Estimated data with little or no verification |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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tilmicosin sulphate | - | Rat | - | ||||
N-desmethyl tilmicosin | - | Animal | - |
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Terrestrial ecotoxicology |
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> 800 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 4710 mg kg feed⁻¹ | E4 E = Manufacturers safety data sheets Anas platyrhynchos4 = Verified data |
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> 918 | E3 E = Manufacturers safety data sheets Eisenia foetida 28 day3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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851 | E4 E = Manufacturers safety data sheets Oncorhynchus mykiss4 = Verified data |
Low | ||||||||
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57.3 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
Moderate | ||||||||
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0.35 | E4 E = Manufacturers safety data sheets Selenastrum capricornutum Growth4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 800 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Very little metabolism, excreted unchanged predominately in the faeces | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Severe allergen Cardiovascular toxicant |
Handling issues |
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May emit toxic fumes when heated to decomposition | |||
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Not listed (Not listed) | |||
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tilmicosin | ||
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tilmicosine | ||
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tilmicosina | ||
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Record last updated: | 20/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |