Diltiazem |
Last updated: 18/05/2024 |
(Also known as: d-cis-diltiazem ) |
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A non-dihydropyridine (non-DHP) veterinary drug usually formulated as the hydrochloride | |
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Current | |
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Used in the treatment of atrial fibrillation, supraventricular tachycardias, hypertrophic cardiomyopathy and hypertension | |
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Dogs; Cats |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₂H₂₆N₂O₄S | |
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CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC | |
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CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC | |
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HSUGRBWQSSZJOP-RTWAWAEBSA-N | |
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InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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diltiazem | - |
General status |
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Vasodilator, Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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A calcium channel blocker | |
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[Voltage-dependent calcium channel gamma-1 subunit, Antagonist] | |
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42399-41-7 | |
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255-796-4 | |
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Cardiobascular system: Calcium channel blockers | |
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QC08DB01 | |
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No | |
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414.52 | |
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cis-(+)-[2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate | |
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White crystalline powder | |
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Formulations |
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Generally formulated as oral tablets using the hydrochloride salt |
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465 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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231 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Decomposes before boiling | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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212 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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6.17 X 1002 | Calculated | - | |||||||
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2.79 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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8.90 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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N-demethyldiltiazem | - | Human (Liver) | - | ||||
deacetyldiltiazem | - | Human | - | ||||
desacetyldiltiazem | - | Human | - |
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Terrestrial ecotoxicology |
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740 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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Aquatic ecotoxicology |
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15.0 | R4 R = Peer reviewed scientific publications Oryzias latipes4 = Verified data |
Moderate | ||||||||
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28.0 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
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General |
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High (class III) | - | - | ||||||||
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740 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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Intraperitoneal LDLo = 220 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 61 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Metabolised in the liver and excreted in the urine | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause anorexia, vomiting, diarrhoea, abdominal pain, paralytic ileus and dyspepsia Teratogenic |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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diltiazem | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |