Tolfenamic acid |
Last updated: 18/05/2024 |
(Not known by any other names) |
|
|
A non-steroidal anti-inflammatory drug (NSAID) which is a structural analogue of flunixin | |
---|---|---|
|
Current | |
|
- | |
|
Used for fever, postoperative pain, and acute and chronic inflammatory conditions | |
|
Cattle; Dogs; Cats; Pigs |
Approval status |
|
Approved | |
---|---|---|
|
Approved |
Chemical structure |
|
- | |
---|---|---|
|
C₁₄H₁₂ClNO₂ | |
|
CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O | |
|
No data | |
|
YEZNLOUZAIOMLT-UHFFFAOYSA-N | |
|
InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18) | |
|
Yes |
|
Common Name | Relationship | Link |
---|---|---|
tolfenamic acid | - |
General status |
|
Anti-inflammatory, Analgesic, Medicinal drug | |
---|---|---|
|
Unclassified substance | |
|
- | |
|
- | |
|
Synthetic | |
|
Directly inhibits prostaglandin receptors | |
|
[Prostaglandin G/H Synthase 1, Antagonist] | |
|
13710-19-5 | |
|
237-264-3 | |
|
- | |
|
- | |
|
- | |
|
Musculo-skeletal system: Non-steroidal anti-inflammatory and antirheumatic products | |
|
QM01AG02 | |
|
No | |
|
Allowed substance (Table 1: Bovine, Porcine) | |
|
261.71 | |
|
- | |
|
2-[(3-chloro-2-methylphenyl)amino]benzoic acid) | |
|
N-(2-methyl-3-chlorphenyl)-anthranilic acid | |
|
- | |
|
- | |
|
- | |
|
Formulations |
|
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Tolfedine 4% w/v Solution for Injection for dogs and cats | Vetoquinol UK | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Tolfedine Tablets 20mg | Vetoquinol UK | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
|
Available in a range of formulations including solutions for injection and tablets |
|
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.78 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
|
- | - | - | ||||||||
|
206 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
1.48 X 1005 | Calculated | - | |||||||
|
5.17 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
|
- |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
- | ||||||||||
|
- |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
- | - | - | ||||||||||||||||||||||||||
|
|
- | - | - | |||||||||||||||||||||||||
|
- | - |
Known metabolites |
None
|
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
225 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
|
|
- | - | - | |||||||
|
- | - | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
- | |||||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
7.4 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - |
|
- | - | - |
|
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
225 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
Intraperitoneal LD₅₀ = 238 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
- | ||||||||
Subcutaneous LD₅₀ = 267 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
- | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
Some metabolisim, the unchanged substance and its glucuronides are predominantly excreted into the bile | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
May cause tremor, euphoria, fatigue and gastrointestinal problems Possible lungs, thorax and respiratory system stimulant |
Handling issues |
|
|
|||
---|---|---|---|---|
|
IMDG TransportHazard Class 6.1 | |||
|
- | |||
|
Not listed (Not listed) | |||
|
UN2811 | |||
|
Packaging Group III (minor danger) - may be product specific | |||
|
- |
|
|
|
||
---|---|---|---|
|
tolfenamic acid | ||
|
acide tolfenamique | ||
|
- | ||
|
- | ||
|
- | ||
|
ácido tolfenámico | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- |
Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |