Cinoxacin |
Last updated: 12/01/2024 |
(Also known as: compound 64716) |
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An oboselete antimicrobial drug used for both humans and, rarely, animals | |
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Coinsidered obsolete but may be available in some countries | |
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1972, patented | |
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Used to treat various infections caused by Gram-negative aerobes | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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- | |
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C₁₂H₁₀N₂O₅ | |
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CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3 | |
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No data | |
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VDUWPHTZYNWKRN-UHFFFAOYSA-N | |
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InChI=1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17) | |
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Yes |
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Common Name | Relationship | Link |
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cinoxacin | - |
General status |
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Antimicrobial, Antibiotic, Antibacterial, Medicinal drug | |
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Quinolone | |
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Synthetic | |
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Inhibits DNA gyrase, thereby inhibiting cell division | |
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[DNA gyrase subunit A, Antagonist], [DNA, intercalation] | |
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28657-80-9 | |
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249-133-8 | |
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Antiinfectives for systemic use: Other quinolones | |
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QJ01MB06 | |
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No | |
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262.22 | |
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1-ethyl-1,4-dihydro- 4-oxo[1,3] dioxolo[4,5-g]cinnoline-3-carboxylic acid | |
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1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid | |
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Pale beige coloured crystalline solid | |
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Formulations |
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961 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
High | ||||||||
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261 | f4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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3.89 X 1001 | Calculated | - | |||||||
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1.59 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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3610 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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73 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Anguilla japonica4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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3610 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Subcutaneous LD₅₀ = 1380 mg kg⁻¹ | L4 L = Pesticide manuals and hard copy reference books / other sources Rat4 = Verified data |
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Intravenous LD₅₀ = 860 mg kg⁻¹ | R4 R = Peer reviewed scientific publications Rat4 = Verified data |
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Rapidly absorbed, some metabolism and excreted in the urine ~60% unchanged | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Gastrointestinal and renal system toxicant causing anorexia, nausea, vomiting, epigastric distress and diarrhoea May cause hyposensitivity |
Handling issues |
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Considered non-hazardous for air and sea shipping | |||
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Not listed (Not listed) | |||
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cinoxacin | ||
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cinoxacine | ||
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cinoxacino | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |