Ramipril (Ref: HOE-498) |
Last updated: 18/05/2024 |
(Not known by any other names) |
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An ACE inhibitor prodrug used in veterinary medicine | |
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Current | |
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Used to treat hypotension and cardiovascular diseases | |
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Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₃H₃₂N₂O₅ | |
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CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCC3CC2C(=O)O | |
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CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O | |
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HDACQVRGBOVJII-JBDAPHQKSA-N | |
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InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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ramipril | - |
General status |
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Antihypertensive agent, Medicinal drug | |
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Unclassified substance | |
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Synthetic | |
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An angiotensin-converting enzyme (ACE) inhibitor | |
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[Angiotensin-converting enzyme, Antagonist] | |
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87333-19-5 | |
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Alimentary tract & metabolism: Agents working on the renin-antiotensin system | |
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QC09AA05 | |
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No | |
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416.51 | |
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(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid | |
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White solid |
Formulations |
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Vasotop tablets | MSD Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually formulated as tablets for oral use |
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107 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.57 X 1003 | Calculated | - | |||||||
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3.41 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.2 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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3.17 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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ramiprilat Note: Pharmacologically active |
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Terrestrial ecotoxicology |
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> 10000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 10000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Intravenous LD₅₀ = 600 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Mostly excreted as the active metabolite by the kidneys | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No further information available |
Handling issues |
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Emits toxic fumes under fire conditions | |||
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Not listed (Not listed) | |||
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ramipril | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |