Pimobendan |
Last updated: 18/05/2024 |
(Also known as: pimobendane; dl-pimobendan) |
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A benzimidazole oral drug used as a heart inodilator | |
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Current | |
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Mainly used to treat congestive heart disease | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₉H₁₈N₄O₂ | |
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CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC | |
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No data | |
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GLBJJMFZWDBELO-UHFFFAOYSA-N | |
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InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24) | |
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Yes |
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Common Name | Relationship | Link |
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pimobendan | Unstated isomer | |
(RS)-pimobendan monohydrate | Hydrate |
General status |
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Cardiovascular Agent, Medicinal drug | |
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Benzimidazole | |
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Synthetic | |
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A calcium sensitiser with positive inotropic and vasodilator effects and also a selective inhibitor of phosphodiesterase III (PDE3). | |
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[Troponin C , Agonist], [Phosphodiesterase (PDE) III, Inhibitor] | |
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74150-27-9 | |
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Cardiovascular system: Cardiac therapy | |
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QC01CE90 | |
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No | |
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334.37 | |
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4,5-dihydro-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-3(2H)-pyridazinone | |
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(RS)-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one | |
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Formulations |
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Cardisan Chewable Tablets | Alfasan Nederland B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Fortekor Plus Tablets | Elanco GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Pimotab ChewableTablets | CP Pharma Handelsgellschaft mbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Zelys Chewable Tablets | Ceva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually supplied in tablet form |
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1.36 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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950 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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950 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Subcutaneous LD₅₀ > 300 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 72 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Elimination is first via excretion in the bile and then faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible endocrine toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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pimobendan | ||
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pimobendane | ||
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pimobendan | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |