Trilostane |
Last updated: 26/04/2024 |
(Also known as: modrastane) |
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An orally active synthetic steroid analogue used in veterinary medicine | |
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Current | |
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2008, USA approved for dogs only | |
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A drug used for the treatment of Cushing's disease (hyperandrenocorticism) | |
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Dogs; Cats; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₀H₂₇NO₃ | |
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CC12CCC3C(C1CCC2O)CCC45C3(CC(=C(C4O5)O)C#N)C | |
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C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CC[C@]45[C@@]3(CC(=C([C@H]4O5)O)C#N)C | |
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KVJXBPDAXMEYOA-CXANFOAXSA-N | |
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InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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trilostane | - |
General status |
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Adrenocortical suppressant, Medicinal drug | |
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Hormone | |
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99% | |
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Natural | |
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An inhibitor of 3 beta-hydroxysteroid dehydrogenase | |
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[3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, Antagonist], [3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II, Antagonist], [Estrogen receptor, modulator], [Estrogen receptor beta, modulator] | |
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13647-35-3 | |
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237-133-0 | |
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656583 | |
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Systemic hormone preparations excluding sex hormones & insulins: Corticosteroids for systemic use | |
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QH02CA01 | |
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No | |
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329.43 | |
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(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo-octadec-4-ene-4-carbonitrile | |
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White to off-white crystalline powder |
Formulations |
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Adrestan Hard Capsules for Dogs | Dechra Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Trilotab Chewable Tablets | CP Pharma Handelsgesellschaft mbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Typically formulated as capsules or chewable tablets for oral administration |
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59.3 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate | ||||||||
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264 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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498 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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255 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.57 X 1002 | Calculated | - | |||||||
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2.41 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.28 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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In ethanol: 252nm = 8300 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.61 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 15000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 15000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ > 7050 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 102 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted primarily in the faeces of the rat, indicating biliary excretion as the major metabolic pathway. In monkeys it is lost in both the urine and faeces. | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause gastrointesinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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trilostane | ||
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trilostano | ||
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Record last updated: | 26/04/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |