Cimetidine |
Last updated: 18/05/2024 |
(Not known by any other names) |
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An antacid and anti-nausea imidazole veterinary drug | |
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Current | |
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1976, UK approval | |
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Mainly used for the treatment and prevention of stomach and intestinal ulcers | |
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Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₀H₁₆N₆S | |
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CC1=C(N=CN1)CSCCNC(=NC)NC#N | |
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AQIXAKUUQRKLND-UHFFFAOYSA-N | |
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InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | |
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Yes |
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Common Name | Relationship | Link |
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cimetidine | - |
General status |
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Gastrointestinal agent, Histamine antagonists, Medicinal drug | |
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Imidazole | |
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Synthetic | |
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Acts by inhibiting gastric acid secretion, as well as pepsin and gastrins output. | |
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[Histamine H2 receptor, Antagonist] | |
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51481-61-9 | |
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257-232-2 | |
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2756 | |
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Alimentary tract & metabolism: Drugs for acid related disorders | |
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QA02BA01 | |
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No | |
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252.34 | |
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2-cyano-1-methyl- 3-(2-[(5-methyl- 1H-imidazol- 4-yl)methylthio]ethyl)guanidine | |
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Crystalline white powder |
Formulations |
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Zitac vet 100 mg tablet for dogs | MSD Animal Health UK Ltd | GB Nationl authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Zitac vet 200 mg tablet for dogs | MSD Animal Health UK Ltd | GB Nationl authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as tablets for oral administration |
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9380 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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142 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.51 X 1000 | Calculated | - | |||||||
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0.40 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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6.8 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Degradation |
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Stable | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Stable | |||||||
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Chemically stable in water | ||||||||||
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4 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Non-persistent | |||||||
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DT₅₀ 2 to 200 hours Lake water | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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cimetidine sulfoxide | - | Human (Urine) | - | ||||
5-hydroxymethyl-cimetidine | - | Human (Urine) | - |
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Terrestrial ecotoxicology |
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2550 | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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> 100 | R4 R = Peer reviewed scientific publications Oryzias latipes4 = Verified data |
Low | ||||||||
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379.7 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Low | ||||||||
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230 | Q3 Q = Miscellaneous data from online sources Daphnia magna3 = Unverified data of known source |
Low | ||||||||
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> 105 | Q3 Q = Miscellaneous data from online sources Selenastrum capricornutum IC503 = Unverified data of known source |
Low | ||||||||
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105 | Q3 Q = Miscellaneous data from online sources Selenastrum capricornutum3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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2550 | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ = 860 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 106 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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About 50% to 80% of an intravenous dose is excreted as unchanged drug in the urine | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause gastrointestinal problems Possible renal toxicant May cause hypotension and bradycardia IARC Group 3 carcinogen - not classifiable |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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cimetidine | ||
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cimetidina | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |