Aminosidine |
Last updated: 12/01/2024 |
(Also known as: amminosidin ; paromomycin; crestomycin; aminosidine I; paramomycin; hydroxymycin) |
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A broad-spectrum aminoglycoside antibiotic drug | |
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Considered obsolete but may be available in some countries | |
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circa 1960, anti-leishmanial activity demonstrated | |
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Used to treat various bacterial infections including colibacillosis and salmonellosis | |
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Cattle; Pigs; Chickens; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₂₃H₄₅N₅O₁₄ | |
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C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N | |
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C1[C@H]([C@@H]([C@H](C([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)OC3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N | |
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UOZODPSAJZTQNH-QGSSWKKLSA-N | |
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InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23+/m1/s1 | |
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Yes |
General status |
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Antibiotic, Antiparasitic, Antibacterial, Medicinal drug, Antiprotozoal | |
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Oligosaccharide | |
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Natural | |
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Has bactericidal properties and inhibits protein synthesis in susceptible bacteria at the 30S ribosomal unit | |
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[30S ribosomal protein S10, Antagonist], [16S rRNA, Antagonist] | |
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7542-37-2 | |
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231-423-0 | |
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165580 | |
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Alimentary tract & metabolism: Intestinal antiinfectants | |
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QA07AA06 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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615.63 | |
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(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol | |
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O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-Streptamine | |
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Solid |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 10000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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503 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 10000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 1010 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 156 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted primarily in the faeces if administered orally but almost exclusively in the urine following parental treatment | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible kidney and liver toxicant May cause gastrointestinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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aminosidine | ||
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paromomycine | ||
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paromomicina | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |