Enoxacin |
Last updated: 19/05/2024 |
(Also known as: AT-2266) |
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A broad-spectrum antibiotic drug particularly effective against gram-negative organisms and staphylococci | |
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1980s, introduced | |
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Used to treat various bacterial infections including those of gums and ears | |
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Cats; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₅H₁₇FN₄O₃ | |
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CCN1C=C(C(=O)C2=CC(=C(N=C21)N3CCNCC3)F)C(=O)O | |
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No data | |
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IDYZIJYBMGIQMJ-UHFFFAOYSA-N | |
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InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23) | |
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Yes |
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Common Name | Relationship | Link |
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enoxacin carboxylate | Variant | |
exoxacin hydrate | Variant |
General status |
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Antibiotic, Antibacterial, Medicinal drug | |
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Fluoroquinolone | |
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Synthetic | |
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Nucleic acid synthesis inhibitor - inhibits DNA gyrase | |
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[DNA gyrase subunit A, Antagonist], [DNA topoisomerase 4 subunit A, Antagonist], [DNA topoisomerase 2-alpha, Antagonist], | |
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74011-58-8 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01MA04 | |
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No | |
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320.32 | |
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1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | |
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1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid | |
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Yellow to white crystalline solid | |
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Formulations |
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3430 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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222 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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5.01 X 10-03 | Calculated | - | |||||||
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-2.3 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low | ||||||||
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1.388 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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6.04 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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6.37 X 10-08 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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3-oxoenoxacin Note: A somewhat pharmacologically active metabolite, less so than parent |
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Terrestrial ecotoxicology |
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> 5000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 236 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Heptic. 44 to 62% of an administered dose is excreted as unchanged drug in urine. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause gastrointestinal problems |
Handling issues |
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May present a fire and explosion hazard Avoid generation of dusts |
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Not listed (Not listed) | |||
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enoxacin | ||
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enoxacine | ||
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enoxacino | ||
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Record last updated: | 19/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |