Pipemidic acid |
Last updated: 19/05/2024 |
(Not known by any other names) |
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An antibacterial drug effective against gram-negative and certain gram-positive bacteria | |
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Used to treat urinary tract infections caused by multiresistant E. coli and Proteus spp. | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₄H₁₇N₅O₃ | |
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CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCNCC3)C(=O)O | |
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No data | |
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JOHZPMXAZQZXHR-UHFFFAOYSA-N | |
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InChI=1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22) | |
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Yes |
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Common Name | Relationship | Link |
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pipemidic acid | - |
General status |
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Antibacterial, Antibiotic, Medicinal drug | |
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Quinolone | |
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Synthetic | |
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Acts by inhibiting bacterial DNA gyrase-dependent processes | |
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[DNA gyrase, Inhibitor] | |
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51940-44-4 | |
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257-530-2 | |
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Antiinfectants for systemic use: Antibacterials for system use | |
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QJ01MB04 | |
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No | |
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303.32 | |
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8-ethyl-5-oxo-2-piperazin-1-yl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid | |
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5,8-dihydro-8-ethyl-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid | |
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Off-white coloured powder |
Formulations |
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322 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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253 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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535 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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277 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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7.94 X 10-03 | Calculated | - | |||||||
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-2.1 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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0.95 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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3.80 X 10-08 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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16000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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> 151 | R4 R = Peer reviewed scientific publications Scenedesmus vacuolatus4 = Verified data |
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General |
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High (class III) | - | - | ||||||||
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16000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ = 1438 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 529 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Between 25 and 88% of orally administered dose is excreted into urine as a bacteriologically act metabolite, other loses occurs via faeces and bile | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Health issues |
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May be harmful is swallowed or inhaled Possible kidney and liver toxicant May cause gastrointestinal problems |
Handling issues |
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No information available | |||
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Health: H317, H334 | |||
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Not listed (Not listed) | |||
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pipemidic acid | ||
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acide pipemidique | ||
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acido pipemidico | ||
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Record last updated: | 19/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |