Vedaprofen |
Last updated: 14/01/2024 |
(Also known as: CERM-10202; PM-150) |
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A non-steroidal anti-inflammatory (NSAID) and analgesic veterinary drug which is structurally related to ketoprofen and carprofen | |
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Current | |
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Used to control pain, especially that associated with musculo-skeletal disorders and traumas | |
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Horses; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₉H₂₂O₂ | |
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CC(C1=CC=C(C2=CC=CC=C21)C3CCCCC3)C(=O)O | |
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No data | |
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VZUGVMQFWFVFBX-UHFFFAOYSA-N | |
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InChI=1S/C19H22O2/c1-13(19(20)21)15-11-12-16(14-7-3-2-4-8-14)18-10-6-5-9-17(15)18/h5-6,9-14H,2-4,7-8H2,1H3,(H,20,21) | |
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Yes |
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Common Name | Relationship | Link |
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vedaprofen | - |
General status |
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Anti-inflammatory, Analgesic, Medicinal drug | |
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Arylpropionic acid | |
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Synthetic | |
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Inhibits phospholipase A2 blocking the formation of chemical mediators leading to peripheral sensitisation and hyperalgesia | |
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[Leukocyte migration, Inhibitor], [Cyclooxygenase, Inhibitor] | |
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71109-09-6 | |
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275-196-6 | |
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Musculo-Skeletal system: Anti-inflammatory and antirheumatic products | |
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QM01AE90 | |
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No | |
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Allowed susbstance (Table 1: Equidae) | |
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282.38 | |
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2-(4-cyclohexylnaphthalen-1-yl)propanoic acid | |
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4-cyclohexyl-α-methylnaphthalene-1-acetic acid | |
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Beige coloured solid |
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Quadrisol 100 mg/ml Oral Gel | Vetcool B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually supplied as a gel or ointment for topical administration |
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150 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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222 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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General |
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High (class III) | - | - | ||||||||
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222 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Largely metabolisd and around 70% excreted in the urine with up to 14% in the faeces. | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause gastrointestinal problems May be ulcerogenic Possible kidney, liver, spleen and thymus toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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vedaprofen | ||
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Record last updated: | 14/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |