Thiamphenicol |
Last updated: 13/01/2024 |
(Also known as: thiophenicol; dextrosulphenidol; Win 5063-2; thiocymetin) |
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A broad spectrum antimicrobial and immunosuppressive substance intended for the treatment of cutaneous infections | |
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Current | |
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Used to treat superficial wound infections such as infectious conjunctivitis, claw and hoof rot, dermatitis | |
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Cattle; Pigs; Poultry; Horses; Goats; Sheep; Mink; Rabbits |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₂H₁₅Cl₂NO₅S | |
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CS(=O)(=O)C1=CC=C(C=C1)C(C(CO)NC(=O)C(Cl)Cl)O | |
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CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O | |
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OTVAEFIXJLOWRX-NXEZZACHSA-N | |
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InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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thiamphenicol | - |
General status |
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Antibiotic, Antimicrobial | |
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Unclassified substance | |
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Synthetic | |
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Peptidyl transferase - inhibits protein synthesis in bacteria. | |
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[Dr hemagglutinin structural subunit, Inhibitor] | |
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15318-45-3 | |
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239-355-3 | |
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Antiinfectants for systemic use: Amphenicols | |
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QJ01BA52 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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356.22 | |
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2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide | |
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2-dichloroacetamido-1-(4-methylsulfonylphenyl)-1,3-propanediol | |
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White crystalline powder | |
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Formulations |
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Taf Cutaneous Spray | Eurovet Animal Health B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Current products are mainly formulated for topical use |
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5.00 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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50 | Q3 Q = Miscellaneous data from online sources Methanol3 = Unverified data of known source |
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20 | Q3 Q = Miscellaneous data from online sources Ethanol3 = Unverified data of known source |
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1.0 | Q3 Q = Miscellaneous data from online sources Ethyl acetate3 = Unverified data of known source |
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1.0 | Q3 Q = Miscellaneous data from online sources Chloroform3 = Unverified data of known source |
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164 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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4.68 X 10-01 | Calculated | - | |||||||
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-0.33 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 3000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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8.86 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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4.06 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 3000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Low | ||||||||
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Intravenous LD₅₀ = 339 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ > 5000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Thiamphenicol is excreted in the urine largely in unchanged | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Possible testes, bone marrow, liver & kidney toxicant Harmful if swallowed May cause gastrointestinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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thiamphenicol | ||
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tiamfenicol | ||
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Record last updated: | 13/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |