Sulphapyridine |
Last updated: 12/01/2024 |
(Also known as: sulfapyridine) |
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A sulfonamide antibiotic drug with veterinary applications | |
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1937, discovered | |
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Typical uses include the treatment of mastitis | |
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Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₁H₁₁N₃O₂S | |
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C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N | |
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No data | |
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GECHUMIMRBOMGK-UHFFFAOYSA-N | |
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InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14) | |
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Yes |
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Common Name | Relationship | Link |
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sulphapyridine | - |
General status |
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Antibacterial, Antibiotic, Antimicrobial, Medicinal drug | |
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Sulfonamide | |
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Synthetic | |
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Inhibits DNA and RNA synthesis | |
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[Dihydropterate synthase, Antagonist] | |
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144-83-2 | |
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205-642-7 | |
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Antiinfectants for systemic use: Antibacterials for system use | |
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QJ01EQ04 | |
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No | |
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249.29 | |
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4-amino-N-pyridin-2-ylbenzenesulfonamide | |
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White to yellow crystalline solid |
Formulations |
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268 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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2.27 | Q3 Q = Miscellaneous data from online sources Ethanol3 = Unverified data of known source |
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15.4 | Q3 Q = Miscellaneous data from online sources Acetone3 = Unverified data of known source |
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192 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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2.24 X 1000 | Calculated | - | |||||||
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0.35 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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8.43 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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8.36 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderately volatile. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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1.09 X 10-11 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Moderately mobile | |||||||
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150 | ||||||||||
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Literature Koc data range 101-308 mL g⁻¹ for silt loam, 80-218 mL g⁻¹ for soil generally | ||||||||||
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 15800 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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0.12 | R2 R = Peer reviewed scientific publications Green algae2 = Unverified data of unknown source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 15800 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intravenous LD₅₀ > 15800 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 1150 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Some metabolism and largely eliminated via the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause dermatological problems including dermatitis May cause gastrointestinal problems Possible blood, bone marrow and kidney toxicant |
Handling issues |
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Non-hazardous for air, sea and road freight Light sensitive |
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Not listed (Not listed) | |||
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sulphapyridine | ||
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2-Sulfanilamidopyridin | ||
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sulfapiridina | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |