Sulphanilamide |
Last updated: 23/02/2024 |
(Also known as: 4-aminobenzenesulphonamide; bacteramid; 4-sulfamoylaniline; PABS; sulphonamide; sulfanilamide) |
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A Sulphonamide antibiotic drug once used in veterinary medicine | |
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Current | |
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1935, active parent introduced | |
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Used to manage bacterial infections notably streptococcal septicaemia, equine pneumonia, strangles, joint-ill and metritis | |
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Cattle; Sheep |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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- | |
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C₆H₈N₂O₂S | |
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C1=CC(=CC=C1N)S(=O)(=O)N | |
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- | |
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FDDDEECHVMSUSB-UHFFFAOYSA-N | |
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InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) | |
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Yes |
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Common Name | Relationship | Link |
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sulphanilamide | - |
General status |
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Antibiotic, Antibacterial, Antimicrobial, Medicinal drug | |
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Soil, Animal, Surface water, Sediment | |
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Sulphonamide substance | |
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Natural | |
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A competitive inhibitor of bacterial enzyme dihydropteroate synthetase | |
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[Dihydropteroate synthase, Antagonist] | |
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63-74-1 | |
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200-563-4 | |
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077902 | |
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Antiinfectants for systemic use: Antibacterials for system use | |
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QJ01EQ06 | |
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No | |
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172.20 | |
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4-aminobenzene-1-sulfonamide | |
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4-aminobenzenesulfonamide | |
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Possible groundwater pollutant | |
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- | |
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Yellow-white coloured solid |
Can be a metabolite of: |
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asulam | Soil | - | Major fraction | |||||
asulam sodium | Soil | 0.139 | Major fraction |
Formulations |
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7500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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165.5 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Decomposes before boiling | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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2.40 X 10-01 | Calculated | - | |||||||
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-0.62 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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10.58 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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0.973 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
Low volatility. If applied directly to plants, drift is a concern & mitigation is advisable | ||||||||
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1.52 X 10-05 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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13.4 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
Non-persistent | |||||||
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13.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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EU dossier Aerobic lab studies DT₅₀ range 3.1-76.3 days, Soils=6 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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2.90 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately mobile | |||||||
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166 | ||||||||||
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0.708 | ||||||||||
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EU dossier Kf range 1.45-4.07 mL g⁻¹, Kfoc range 96-278 mL g⁻¹, 1/n range 0.673-0.748, Soils=8 | ||||||||||
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Fate indices |
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2.01 | Calculated | Transition state | ||||||||||||||||||||||||||
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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3700 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Low | ||||||||
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> 1000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida5 = Verified data used for regulatory purposes |
Low | ||||||||
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3.75 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Nitrogen mineralisation: No significant adverse eff | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Dose: 3.3 mg kg⁻¹ soil 28 Day |
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Aquatic ecotoxicology |
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2.3 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Lemna minor5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 21.15 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pseudokirchneriella subcapitata 120 hr4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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3700 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Low | ||||||||
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255 | E3 E = Manufacturers safety data sheets Rat 4 hr3 = Unverified data of known source |
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Intravenous LD₅₀ = 1400 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 2900 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Excreted mainly in the urine but can also be found in most dody fluids including breast milk | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Ingestion may cause allergic reactions Long-term use may cause cancer of the thyroid gland Published studies suggest substance is carcinogenic |
Handling issues |
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IMDG Transport Hazard Class 8 Corrosive solid |
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Not listed (Not listed) | |||
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UN1759 | |||
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sulphanilamide | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |