Gamithromycin |
Last updated: 14/01/2024 |
(Not known by any other names) |
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A macrolide veterinary drug active in vitro against certain bacterial agents | |
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Current | |
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Used to treat bovine respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni | |
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Cattle; Pigs; Sheep |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₄₀H₇₆N₂O₁₂ | |
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CCCN1CC(C(C(C(OC(=O)C(C(C(C(C(CC1C)(C)O)OC2(C(C(CC(O2)C)N(C)C)O)C)C)OC3CC(C(C(O3)C)O)(C)OC)C)CC)(C)O)O)C | |
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CCCN1C[C@@H]([C@H]([C@]([C@H](OC(=O)[C@@H]([C@H]([C@@H]([C@H]([C@](C[C@H]1C)(C)O)O[C@]2([C@@H]([C@H](C[C@H](O2)C)N(C)C)O)C)C)O[C@H]3C[C@]([C@@H]([C@H](O3)C)O)(C)OC)C)CC)(C)O)O)C | |
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IMIKDFRXJJEHPP-KXHBJKOVSA-N | |
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InChI=1S/C41H78N2O12/c1-16-18-43-22-23(3)33(44)40(11,49)30(17-2)52-37(47)27(7)32(53-31-21-39(10,50-15)34(45)28(8)51-31)26(6)36(38(9,48)20-24(43)4)55-41(12)35(46)29(42(13)14)19-25(5)54-41/h23-36,44-46,48-49H,16-22H2,1-15H3/t23-,24+,25+,26-,27+,28+,29-,30+,31-,32-,33+,34+,35+,36+,38+,39-,40+,41-/m0/s1 | |
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Yes |
General status |
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Antimicrobial, Antibiotic, Antibacterial, Medicinal drug | |
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Macrolide | |
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Semi-synthetic | |
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Broad spectrum, distrupts bacterial protein synthesis | |
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[50S rRNA, Antagonist] | |
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145435-72-9 | |
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Antiinfectives for systemic use: Antibacterials for systemic use | |
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QJ01FA95 | |
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No | |
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Allowed substance (Table 1: Bovine) | |
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777.04 | |
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(2R,3S,5R,6R,8R,11S,12R,13S,14R)-5-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-6,12,13-trihydroxy-3-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,6,8,11,13-hexamethyl-9-propyl-15-oxa-9-azacyclopentadecan-1-one | |
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3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one | |
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White to beige coloured crystalline powder |
Formulations |
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Zactran 150 mg/ml solution for injection | Boehringer Ingelheim Vetmedica GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually formulted as solutions for injection |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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0.01 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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Eliminated primarily via the faeces (around 40-60%) and lesser amounts (<20%) in the urine | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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gamithromycin | ||
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Record last updated: | 14/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |