Cilostazol (Ref: OPC-13013) |
Last updated: 19/05/2024 |
(Also known as: cilostazolum; cilostazole) |
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A novel quinolone drug being explored for veterinary applications | |
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Used as an alternative medical treatment for canine bradyarrhythmia | |
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Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₀H₂₇N₅O₂ | |
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C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4 | |
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No data | |
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RRGUKTPIGVIEKM-UHFFFAOYSA-N | |
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InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) | |
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Yes |
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Common Name | Relationship | Link |
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cilostazol | - |
General status |
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Antiplatelet agent, Antithrombotic agent, Medicinal drug | |
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Quinolone | |
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Synthetic | |
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A selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on increasing cAMP | |
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[cGMP-inhibited 3',5'-cyclic phosphodiesterase A, Antagonist] | |
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73963-72-1 | |
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Blood and blood forming organs: Antithrombotic agents | |
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QB01AC23 | |
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No | |
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369.46 | |
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6-(4-(1-cyclohexyl-1H-1,2,3,4-tetrazol-5-yl)butoxy)-1,2,3,4-tetrahydroquinolin-2-one | |
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6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-,4-dihydro-2(1H)-quinolinone | |
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White crystalline powder |
Formulations |
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160 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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2.00 X 1002 | Calculated | - | |||||||
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2.3 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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3,4-dihydro-6-[4-(1-(trans-4-hydroxycyclohexyl-1H-tetrazol-5-yl)butoxy]-2(1H-quinolinone) (Ref: OPC-13213) Note: Pharmacologically active |
HC; 4'-trans-hydroxycilostazol | Rat (Urine) | ~0.3% administered dose | ||||
(6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)- butoxy]-2(1H-quinolinone) (Ref: OPC-13015) Note: Pharmacologically active |
DHC; 3,4-dehydrocilostazol | Rat (Urine) | ~0.02% administered dose | ||||
[6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-4-hydroxy-2(1H)-quinolinone] (Ref: OPC-13326) Note: Pharmacologically active |
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3,4-dihydro-6-[4-[1-(cis-4-hydroxycyclohexyl)-1H-tetrazol-5-yl)butoxy]-2(1H)-quinolinone)]. (Ref: OPC-13217) Note: Pharmacologically active |
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Ref: OPC-13366 | - | - | - | ||||
Ref: OPC-13388 | - | - | - | ||||
Ref: OPC-13269 | - | - | - |
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Terrestrial ecotoxicology |
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intramuscular LD₅₀ > 1000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Fully metabolised which are largely excreted in the urine with <20% being eliminated in the faeces | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause headaches and gastrointestinal problems May cause hypertension |
Handling issues |
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{No information available | |||
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Not listed (Not listed) | |||
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cilostazol | ||
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Record last updated: | 19/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |