Allethrin (Ref: FMC 249) |
Last updated: 24/08/2024 |
(Also known as: palléthrine; S-bioallethrin; toluen-disocianato; esdepallethrine; d-allethrolone chrysanthemumate) |
SUMMARY |
Allethrin is a pyrethroid insecticide mostly used in amenity and domestic situations. It has a low aqueous solubility, is volatile and, based on its chemical properties, would not be expected to leach to groundwater. It tends to be moderately persistent in most soil systems. Allethrin is moderately toxic to mammals and a recognised irritant. Whilst it is not highly toxic to birds it is moderately toxic to fish, honeybees and earthworms. |
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A pyrethroid insecticide used in veterinary medicine to control parasites | |
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Current | |
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1949, first introduced; circa 1954, first registered Japan | |
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Used to control general livestock insect pests as well as fleas and ticks in domestic animals | |
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Cattle; Cats; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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A chiral molecule. Allethrin is a isomeric mixture of 8 stereoisomers. | |
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C₁₉H₂₆O₃ | |
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CC1=C(C(=O)CC1OC(=O)C2C(C2(C)C)C=C(C)C)CC=C | |
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- | |
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ZCVAOQKBXKSDMS-UHFFFAOYSA-N | |
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InChI=1S/C19H26O3/c1-7-8-13-12(4)16(10-15(13)20)22-18(21)17-14(9-11(2)3)19(17,5)6/h7,9,14,16-17H,1,8,10H2,2-6H3 | |
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Yes |
General status |
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Antiparasitic | |
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Pyrethroid insecticide | |
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93% | |
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- | |
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Synthetic | |
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Stomach and respiratory action, non-systemic, paralyses insects before killing them. | |
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[Sodium & Chloride channels, Blocker] | |
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584-79-2 | |
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209-542-4 | |
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267 | |
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004001/004003 | |
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11442 | |
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006-025-00-3 | |
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Antiparasitic products, insecticides & repellents: Pyrethrins & pyrethroids | |
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QP53AC | |
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No | |
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- | |
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302.41 | |
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(1E)-2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl (1?,3?)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate | |
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1RS)-3-allyl-2-methyl-4-oxocyclopent-2-enyl (1RS,3RS;1RS,3SR)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate | |
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2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate | |
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- | |
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- | |
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Viscous amber liquid | |
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Formulations |
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0.0001 | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data |
Low | ||||||||
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Miscible | R3 R = Peer reviewed scientific publications Acetone3 = Unverified data of known source |
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Miscible | R3 R = Peer reviewed scientific publications Ethanol3 = Unverified data of known source |
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655000 | E3 E = Manufacturers safety data sheets Hexane3 = Unverified data of known source |
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281.5 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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87 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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9.12 X 1004 | Calculated | - | |||||||
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4.96 | P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data |
High | ||||||||
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1.01 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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0.78 | R4 R = Peer reviewed scientific publications at 25°C4 = Verified data |
Low volatility. If applied directly to plants, drift is a concern & mitigation is advisable | ||||||||
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6.20 X 10-07 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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60 | DW4 DW = Don Wauchope personal database for Pka data: Wauchope, R. D. and Edwards, J. Dissociation constants for pesticide active ingredients: a database and comparison with predicted values. Dataset is no longer available. 4 = Verified data |
Moderately persistent | |||||||
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- | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Decomposes rapidly in UV light | ||||||||||
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- | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Hydrolysis occurs only under alkaline conditions | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | DW3 DW = Don Wauchope personal database for Pka data: Wauchope, R. D. and Edwards, J. Dissociation constants for pesticide active ingredients: a database and comparison with predicted values. Dataset is no longer available. 3 = Unverified data of known source |
Slightly mobile | |||||||
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1400 | ||||||||||
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Other sources: 9500 mL g⁻¹ (CB2) | ||||||||||
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Fate indices |
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1.52 | Calculated | Low leachability | ||||||||||||||||||||||||||
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200 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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685 | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) Rat4 = Verified data |
Moderate | ||||||||
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> 2030 | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) Colinus virginianus4 = Verified data |
Low | ||||||||
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> 1000 | Q3 Q = Miscellaneous data from online sources Unknown species3 = Unverified data of known source |
Low | ||||||||
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> 3.4 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Moderate | |||||||
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Aquatic ecotoxicology |
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> 0.019 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss4 = Verified data |
High | ||||||||
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0.005 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Cyprinus carpio4 = Verified data |
High | ||||||||
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> 1.99 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio4 = Verified data |
Moderate | ||||||||
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> 0.021 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
High | ||||||||
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General |
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Intermediate (class II) | - | - | ||||||||
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685 | G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) Rat4 = Verified data |
Moderate | ||||||||
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2660 | L3 L = Pesticide manuals and hard copy reference books / other sources Rabbit3 = Unverified data of known source |
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> 3.88 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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Low risk to Europeans as no longer approved for use | |||||||||
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Exposure may occur via skin contact or inhalation - PPE/PPC advised | ||||||||||
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Urinary (25 - 50%) and faecal (50-70%) in around 3 days | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Moderately toxic Potential mutagen Kidney and liver toxicant Inhalation may cause asthma, coughing, wheezing, running nose and eyes |
Handling issues |
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Incompatible with alkalis Sensitive to light |
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Health: H302, H332 Environment: H400, H410 |
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II (Moderately hazardous) | |||
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allethrin | ||
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allethrine | ||
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Allethrin | ||
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d-trans-allethrin | ||
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alletrina | ||
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aletrina | ||
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allethrin bioallethrin | ||
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aletryna | ||
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- | ||
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allethrin | ||
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Record last updated: | 24/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |