Streptomycin sulphate |
Last updated: 22/08/2024 |
(Also known as: Streptomycin sesquisulfate; Streptomycin A1; phytomycin; streptomycin sulfate; crop antibiotic) |
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A narrow spectrum aminoglycoside antibiotic used in veterinary medicine | |
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Used for the management of bacterial infections such as E. coli, Klebsiella and some species of Proteus, Pasteurella and Salmonella | |
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Cattle; Sheep; Horses, Cats, Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Streptomycin sulphate is a chiral molecule | |
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CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O | |
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C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O | |
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QTENRWWVYAAPBI-YCRXJPFRSA-N | |
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InChI=1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;;;/m00.../s1 | |
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Yes |
General status |
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Crop antibiotic, Antibacterial, Medicinal drug | |
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Bactericide | |
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Micro-organism derived substance | |
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Natural | |
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A aminoglycoside that inhibites protein biosynthesis bybinding to the 30S subunit of the bacterial ribosome, systemic action | |
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3810-74-0 | |
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223-286-0 | |
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Antiinfectants for systemic use: Antibacterrials for systemic use | |
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QJ01GA01 | |
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No | |
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Allowed substance (Table 1: Ruminants, Porcine, Rabbits) | |
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1457.4 | |
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2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;sulfuric acid | |
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White to pale yellow hydroscopic powder with meal-like odour |
Formulations |
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Multiject IMM Intrammmary Suspension | Norbrook Laboratories Ltd | UK National authorisation | POM-V | ||||||
Pen and Strep Suspension for Injection | Norbrook Laboratories Ltd | UK National authorisation | - | |||||||
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Usually formulated s a solution for injection |
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100,000 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 9000 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
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> 4640 | E4 E = Manufacturers safety data sheets Anas platyrhynchos4 = Verified data |
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> 100 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Apis mellifera3 = Unverified data of known source |
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Aquatic ecotoxicology |
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> 180 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
Low | ||||||||
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650 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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> 9000 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
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600 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 500 mg kg⁻¹ | R3 R = Peer reviewed scientific publications Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 90.2 mg kg⁻¹ | R3 R = Peer reviewed scientific publications Mouse3 = Unverified data of known source |
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Poorly and irregularly absorbed form the gastrointestinal tract. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No further information available |
Handling issues |
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Incompatible with strong oxidizing agents | |||
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Not listed (Not listed) | |||
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streptomycin sulphate | ||
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Record last updated: | 22/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |