Emamectin B1b |
Last updated: 31/05/2024 |
(Not known by any other names) |
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A semi-synthetic avermectin that is clinically used in veterinary medicine for its anti-helminthic and anti-parasitic activity. Normally used as the benzoate. | |
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Current | |
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1997, introduced Israel and Japan; 1999, introduced USA | |
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Used for the treatment of heartworm, hookworm, threadworm and whipworm. It is also used to control sea lice in marine cage fish | |
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Caged fish; Cats; Dogs |
Approval status |
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Chemical structure |
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Emamectin B1b is a complex molecule with multiple chiral centres. | |
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C₄₈H₇₃NO₁₃ | |
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CC1C=CC=C2COC3C2(C(C=C(C3O)C)C(=O)OC4CC(CC=C(C1OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)NC)OC)OC)C)OC7(C4)C=CC(C(O7)C(C)C)C)O | |
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C[C@H]1/C=C/C=C/2\CO[C@H]3[C@@]2([C@@H](C=C([C@H]3O)C)C(=O)O[C@H]4C[C@@H](C/C=C(/[C@H]1O[C@H]5C[C@@H]([C@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)NC)OC)OC)\C)O[C@]7(C4)C=C[C@@H]([C@H](O7)C(C)C)C)O | |
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DXIOOXFZLKCVHK-VAUHGISYSA-N | |
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InChI=1S/C48H73NO13/c1-25(2)42-28(5)17-18-47(62-42)23-34-20-33(61-47)16-15-27(4)43(26(3)13-12-14-32-24-55-45-41(50)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-11)44(31(8)57-39)60-38-21-36(53-10)40(49-9)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,16,20-24H2,1-11H3/b13-12+,27-15+,32-14+/t26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41+,42+,43-,44-,45+,47+,48+/m0/s1 | |
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Yes |
General status |
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Antiparasitic | |
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Bactericide | |
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Micro-organism derived substance | |
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Non-systemic, acts by causing insect paralysis. Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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121424-52-0 | |
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791 | |
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Antiparasitic products, insecticides & repellents: Avermectins | |
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QP54AA06 | |
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872.1 | |
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(10E,14E,16E)-(1R,4S,5S,6S,6R,8R,12S,13S,20R,21R,24S)-21,24-dihydroxy--6-isopropyl-5,11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.1.0]pentacosa-10,14,16,22-tetraene)-6-spiro-2Œ-(5,6-dihydro-2H-pyran)-12-yl 2,6-dideoxy-3-O-methyl-4-O-(2,4,6-trideoxy-3-O-methyl-4-methylamino-α-L-lyxo-hexapyranosyl)-)-α-L-arabino-hexapyranoside | |
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(4R)-5-O-demethyl-25-de(1-methylpropyl)-4-deoxy-4-(methylamino)-25-(1-methylethyl)-avermectin A1a | |
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White or faintly yellow powder | |
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Formulations |
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21 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data |
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1.00 X 1005 | Calculated | - | |||||||
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5.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Soluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Regulatory data - observed in metabolism and farm animal feeding studies | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil metabolites |
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Known groundwater metabolites |
None
Other known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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Health issues |
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May cause climical tremors |
Handling issues |
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Not explosive or oxidising Not explected to auto-ignite, Not highly flammable |
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Health: H301, H311, H331, H372, H318, H319 Environment: H400 |
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Not listed (Not listed) | |||
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emamectin B1b | ||
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Record last updated: | 31/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |