Crotamiton |
Last updated: 24/07/2024 |
(Also known as: crotamitone) |
SUMMARY |
Crotamiton is an anti-infective substance with action against scabies. It is highly volatile. Little data is available regarding its environmental fate or ecotoxicity. It has a moderate mammalian oral toxicity. |
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A scabicidal and antipruritic agent available as a cream or lotion for topical use only | |
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Considered obsolete but may be available in some countries | |
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Used to treat scabies and irritable skin conditions | |
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Sheep |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric. The technical material is a mix of the cis- and trans-forms | |
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C₁₃H₁₇NO | |
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CCN(C1=CC=CC=C1C)C(=O)C=CC | |
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CCN(C1=CC=CC=C1C)C(=O)/C=C/C | |
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DNTGGZPQPQTDQF-XBXARRHUSA-N | |
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InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+ | |
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Yes |
General status |
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Scabicide, Ectoparasiticide, Insecticide, Acaracide | |
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Anilide insecticide; Anilide acaricide | |
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>98% | |
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Synthetic | |
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Inhibits TRPV4 (transient receptor potential vanilloid 4) channel that is expressed in the skin and primary sensory neuron | |
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483-63-6 | |
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207-596-3 | |
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None allocated | |
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055701 | |
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688020 | |
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No data found | |
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Antiparasitic products, Insecticides and Repellents: Ectoparasiticides, Insecticides and Repellents | |
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QP53AX04 | |
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No | |
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203.28 | |
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(2E)-N-ethyl-N-(2-methylphenyl)but-2-enamide | |
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(E)-N-ethyl-N-(2-methylphenyl)but-2-enamide | |
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(2E)-N-ethyl-N-(2-methylphenyl)-2-butenamide | |
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Groundwater pollutant | |
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Colourless or pale-yellow oily liquid with faint amine-like odour |
Formulations |
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Eurax | Novartis | Not licensed | Not licensed | ||||||
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Formulated as an ointment or lotion for topical use |
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Miscible | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Methanol3 = Unverified data of known source |
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25 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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307 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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235 | E3 E = Manufacturers safety data sheets (closed cup)3 = Unverified data of known source |
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5.37 X 1002 | Calculated | - | |||||||
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2.73 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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65.2 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Highly volatile. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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1600 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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1600 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 318 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneaus LD₅₀ = 1630 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Rapidly excreted in the urine | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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Absorbed systemically through the skin May cause an allergic skin reaction |
Handling issues |
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Not compatible with oxidising agents Emits toxic fumes under fire conditions |
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Not classified: Obsolete | |||
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Not listed (Not listed) | |||
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crotamiton | ||
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crotamiton | ||
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Record last updated: | 24/07/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |