Maduramicin |
Last updated: 09/02/2024 |
(Also known as: CL 259971 ; maduramicin ammonia) |
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A veterinary substance with antiprotazoal activity first isolated from actinomycete which is now considered to be obsolete | |
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Obsolete | |
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Circa 1986, first regulatory submission USA | |
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Once used to treat coccidiosis in poultry | |
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Poultry |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₄₇H₈₃NO₁₇ | |
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CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)[O-])O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C.[NH4+] | |
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C[C@H]1C[C@H]([C@@](O[C@@H]1[C@H]2C[C@@H]([C@@H](O2)[C@@]3(CC[C@@H](O3)[C@@]4(CC[C@@]5(O4)C[C@@H]([C@H]([C@H](O5)[C@@H](C)[C@H]6[C@@H]([C@H]([C@@H]([C@](O6)(CC(=O)[O-])O)C)OC)OC)C)O)C)C)O[C@@H]7C[C@@H]([C@H]([C@@H](O7)C)OC)OC)(C)O)C.[NH4+] | |
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WQGJEAMPBSZCIF-HKSLRPGUSA-N | |
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InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50;/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50);1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+;/m0./s1 | |
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Yes |
General status |
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Antiprotozoal agent, Medicinal drug, Antibacterial, Antibiotic | |
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Monoglycoside polyether (ionophore) | |
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Natural | |
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Acts by affecting cation transport across the cell membrane, increasing the influx of Ca+, Na+, and K+ in the cell wall thereby causing cell membrane disruption and cell death. | |
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[Cell proliferation, Inhibitor] | |
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84878-61-5 | |
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Antiprotozals: Agents again protozoal diseases | |
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QP51AX10 | |
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No | |
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934.16 | |
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azanium;2-[(2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-[(2R,3S,5R)-3-[(2R,4S,5S,6S)-4,5-dimethoxy-6-methyloxan-2-yl]oxy-5-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]oxolan-2-yl]-5-methyloxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]ethyl]-2-hydroxy-4,5-dimethoxy-3-methyloxan-2-yl]acetate | |
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maduramicn ammonium | |
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White solid |
Formulations |
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Cygro 1% premix | Alpharma Canada Corp. | Not licensed | Not licensed | ||||||
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165 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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2.51 X 1003 | Calculated | - | |||||||
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3.4 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
High | ||||||||
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1.18 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Mo significant absorbance between 290 and 750nm | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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Literature states rapid degradation in soil. DT₅₀ in chicken excreta measure by antibiotic acivity is about 55 days. | ||||||||||
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55 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Temperature dependent3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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5.0 | E3 E = Manufacturers safety data sheets Salmo gairdneri3 = Unverified data of known source |
Moderate | ||||||||
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7.5 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Over 90% lost in excreta unchanged | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Health issues |
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May cause muscle weakness & myonecrosis May cause renal failure Highly toxic |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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maduramicin | ||
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maduramicine | ||
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Kaduramicina | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |