Nigericin (Ref: N1495) |
Last updated: 19/05/2024 |
(Also known as: Polyetherin A; Antibiotic X-464 ) |
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Broad spectrum ionophore antibiotic, derived from Streptomyces hygroscopicus, used in veterinary medicine to control gram-positive bacteria | |
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1950s, first described | |
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Once widely used as a ruminant non-hormonal growth promoter. Also used as a coccidiostatic agent | |
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Cattle; Poultry; Sheep; Goats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₄₀H₆₈O₁₁ | |
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CC1CCC(OC1C(C)C(=O)O)CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC | |
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C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC | |
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DANUORFCFTYTSZ-SJSJOXFOSA-N | |
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InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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nigericin | - |
General status |
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Antibiotic, Antibacterial, Coccidiostat | |
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Polyether (ionophore) | |
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>98% | |
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Natural | |
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A protein transport inhibitor, inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. | |
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[Insulin-stimulated glucose transport in 3T3-L1 adipocytes., Inhibitor] | |
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28380-24-7 | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals | |
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QP51AH03 | |
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No | |
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724.96 | |
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(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid | |
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Nigericin | |
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White solid |
Formulations |
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Nigericin, free acid | Life Technologies, Canada | Not licensed | Not licensed | ||||||
Nigericin | Ausmausco Pharma, Co., Ltd. | Not licensed | Not licensed | |||||||
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0.01 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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5000 | E3 E = Manufacturers safety data sheets Ethanol3 = Unverified data of known source |
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183 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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780 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.19 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.54 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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190 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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190 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Moderate | ||||||||
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Intraperitoneal LD₅₀ = 2.5 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Health issues |
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Toxic if ingested |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Health: H301, H335, H315, H319 | |||
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Not listed (Not listed) | |||
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UN3462 | |||
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Packaging Group III (minor danger) | |||
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Record last updated: | 19/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |