Valinomycin |
Last updated: 23/05/2024 |
(Also known as: Antibiotic N-329 B) |
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A potent antibiotic active again gram-positive bacteria and shown to also have antiviral properties, Reported to be a potent agent against SARS-CoV in humans | |
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Novel | |
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1955, first isolated; 1960, first recognised as a potassium-selective ionophore | |
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Currently mainly used for research purposes | |
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Cattle; Sheep |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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₅₄H₉₀N₆O₁₈ | |
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CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C | |
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No data | |
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FCFNRCROJUBPLU-GGUWDUSBSA-N | |
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InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66 | |
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Yes |
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Common Name | Relationship | Link |
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valinomycin | - |
General status |
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Antibiotic, Coccidiostats | |
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Ionophore drug; Micro-organism derived drug | |
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Natural | |
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Induces cell death, increaes the transport of potassium ions across cell membranes | |
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2001-95-8 | |
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217-896-6 | |
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No | |
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1111.32 | |
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cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-Lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl) | |
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1,7,13,19,25,31-Hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone, 12,24,36-trimetyl-3,6,9,15,18,21,27,30,33-nonakis(1-methylethyl)- | |
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White solid |
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172 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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3.09 X 1004 | Calculated | - | |||||||
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4.49 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.060 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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4.0 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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4.0 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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5.0 | E3 E = Manufacturers safety data sheets Rabbit3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 39 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 4.14 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Health issues |
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Very toxic by ingestion, dermal contact and inhalation Possible cardiovascular system, eyes and nervous system toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 May emit toxic fumes when heated Corrosive |
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Health: H300, H310 | |||
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group I (great danger) | |||
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valinomycin | ||
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Record last updated: | 23/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |