Atipamezole hydrochloride (Ref: NSC 71310) |
Last updated: 21/05/2024 |
(Also known as: atipamezole HCl) |
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A veterinary drug for the reversal of the sedative effects and cardiovascular effects following application of certain drugs | |
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Current | |
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1996, first US approval | |
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Used to reverse the sedative and analgesic effects of the drugs dexmedetomidine and medetomidine. | |
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Dogs; Cats; Elephants; Bears; Ferrets; Apes |
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Approved | |
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Approved |
Chemical structure |
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C₁₄H₁₇ClN₂ | |
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CCC1(CC2=CC=CC=C2C1)C3=CN=CN3.Cl | |
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PCCVCJAQMHDWJY-UHFFFAOYSA-N | |
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InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H | |
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Yes |
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Common Name | Relationship | Link |
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atipamezole hydrochloride | Parent |
General status |
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Sedative antidote | |
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Unclassified substance | |
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Synthetic | |
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Alpha2 adrenergic receptor antagonist which selectively and competitively inhibits alpha2-adrenergic receptors | |
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[Alpha-2 adrenergic receptor, Antagonist] | |
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13649426 | |
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Antidotes: Atipramezole | |
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QV03AB90 | |
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No | |
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248.75 | |
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5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole; hydrochloride | |
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Crystalline solid |
Formulations |
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Antisedan | Orion Corps | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Sedastop 5 solution for injection | Le Vet B.V. | GB National Authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Antipam 5.0 mg/ml solution for injection | Eurovet Animal Health B.V. | GB National Authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Revertor 5 mg/ml solution for injection | CP Pharma | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated as a solution for injection |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 50 | P3 P = Other non-EU, UK or US Governments and Regulators Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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> 50 | P3 P = Other non-EU, UK or US Governments and Regulators Rat3 = Unverified data of known source |
High | ||||||||
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Subcutaneous TDLo = 0.1 mg kg⁻¹ | R3 R = Peer reviewed scientific publications Rat3 = Unverified data of known source |
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Metabolised in the liver and rapidly (2-3 hrs) eliminated in urine. | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause cardiovascular effects Possible CNS toxicant |
Handling issues |
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Not compatible with strong oxidising agents Will release toxic gases if heated to decomposition |
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Health: H301, H311, H331 | |||
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Not listed (Not listed) | |||
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None allocated | |||
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atipamezole hydrochloride | ||
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Record last updated: | 21/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |