Pantoprazole |
Last updated: 11/01/2024 |
(Not known by any other names) |
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A human and veterinary proton pumb inhibitor drug used to reduce gastric acid secretion | |
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Used to treat erosive esophagitis and other conditions involving excess stomach acid | |
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Dogs; Cats; Llamas & Alpacas |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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The technical material is a 1 : 1 racemate mixture | |
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C₁₆H₁₅F₂N₃O₄S | |
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COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC | |
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No data | |
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IQPSEEYGBUAQFF-UHFFFAOYSA-N | |
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InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21) | |
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Yes |
General status |
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Medicinal drug: Proton pump inhibitor | |
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Unclassified substance | |
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Inhibits gastic acid secretion by inhibiting the K+/H+ pump | |
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[Potassium-transporting ATPase alpha chain 1, Inhibitor] | |
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102625-70-7 | |
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4679 | |
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Alimentary tract and metabolism Drugs for acid related disorders | |
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QA02BD11 | |
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No | |
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383.37 | |
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6-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H-benzimidazole | |
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6-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H-benzimidazole | |
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Off-white coloured powdery solid |
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Protonix | Pfizer | Not licensed | Not licensed | ||||||
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48 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
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Decomposes before melting | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Decomposes before boliing | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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139 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.58 X 1002 | Calculated | - | |||||||
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2.2 | V2 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) estimated2 = Unverified data of unknown source |
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3.92 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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pKa(2)=8.19 | |||||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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747 | P4 P = Other non-EU, UK or US Governments and Regulators Rat4 = Verified data |
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Aquatic ecotoxicology |
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> 95 | P4 P = Other non-EU, UK or US Governments and Regulators Pimephales promelas4 = Verified data |
Moderate | ||||||||
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> 95 | P4 P = Other non-EU, UK or US Governments and Regulators Daphnia magna4 = Verified data |
Moderate | ||||||||
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48 | P4 P = Other non-EU, UK or US Governments and Regulators Pseudokirchneriella subcapitata4 = Verified data |
Low | ||||||||
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General |
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747 | P4 P = Other non-EU, UK or US Governments and Regulators Rat4 = Verified data |
Moderate | ||||||||
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Intravenous LD₅₀ = 256 mg kg⁻¹ | P4 P = Other non-EU, UK or US Governments and Regulators rat4 = Verified data |
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Occupational exposure to pantoprazole may occur through inhalation and dermal contact | ||||||||||
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Heptic metabolism, renal elimination within a few hours | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and joint pain May cause hypergastrinemia Possible link with gastric cancer |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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pantoprazole | ||
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Record last updated: | 11/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |