Ephedrine |
Last updated: 21/05/2024 |
(Also known as: (-)-(1R,2S)-ephedrine; L-(-)-ephedrine ) |
SUMMARY |
Phenethylamine |
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A veterinary and human drug used to contrict blood vessels and widen bronchial passages. It is often formulated using the hydrochloride salt. | |
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Current | |
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Used to relieve breathing and/or urinary difficulties | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Ephedrine is a chiral molecule. | |
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C₁₀H₁₅NO | |
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CC(C(C1=CC=CC=C1)O)NC | |
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C[C@@H]([C@@H](C1=CC=CC=C1)O)NC | |
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KWGRBVOPPLSCSI-WPRPVWTQSA-N | |
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InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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ephedrine | - | |
ephidrine hydrochloride | Variant |
General status |
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Medicinal drug: Nervous system stimulant, Bronchodilator agent | |
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Sympathomimetic amine | |
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Synthetic | |
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Indirect stimulation of the adrenergic receptor system by increasing the activity of norepinephrine at the postsynaptic a- and ß-receptors. | |
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[Sodium-dependent noradrenaline transporter, Inverse agonist], [Alpha-1A adrenergic receptor, Unknown activity], [Synaptic vesicular amine transporter, Inhibitor] | |
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299-42-3 | |
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321-98-2; 4607-45-8; 90-81-3 | |
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202-017-0 | |
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9294 | |
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Urologicals: Other urologicals | |
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QG04BX90 | |
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No | |
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165.23 | |
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(1R,2S)-2-(methylamino)-1-phenyl-1-propanol | |
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(1R,2S)-2-(methylamino)-1-phenyl-1-propanol | |
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(-)-a-(1-methylaminoethyl)benzyl alcohol | |
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Ephedrine may interact with other sympathomimetics. | |
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Crystalline solid | |
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Formulations |
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Enurace Tablets | Ecuphar NV | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Available in tablet form |
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63600 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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34 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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255 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.35 X 1001 | Calculated | - | |||||||
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1.13 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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10.25 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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600 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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562 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Unknown species3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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600 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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Subcutaneous LD₅₀ = 300 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LDLo = 150 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Renally eliminated mostly as unchanged drug | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May invoke weight loss & nausea Possible CNS toxicant May cause flushing, sweating & acne vulgaris |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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ephedrine | ||
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Record last updated: | 21/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |